Structure and function of the epidermal barrier in patients with atopic dermatitis – treatment options. Part one

Jagoda Pelc; Magdalena Czarnecka-Operacz; Zygmunt Adamski

doi:10.5114/ada.2018.73159

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Structure and function of the epidermal barrier in patients with atopic dermatitis – treatment options. Part one

Jagoda Pelc

,

Magdalena Czarnecka-Operacz

,

Zygmunt Adamski

Adv Dermatol Allergol 2018; XXXV (1): 1-5

DOI: https://doi.org/10.5114/ada.2018.73159

Online publish date: 2018/02/20

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Atopic dermatitis is a chronic, recurrent inflammatory skin disease, which is frequently familial. The main cause of the disease seems to be a defect of the epidermal barrier resulting from a genetic predisposition concerning the epidermis, functioning of the immune system as well as environmental factors (which are not related to the immune system). Genes responsible for encoding protein S100, filaggrin, proteases and their inhibitors are the main genes related to the problem of epidermal barrier dysfunction. There is a close connection between structural and immunological processes. Increased expression of cytokine Th2 profile belongs to the latter category. The objective of the present paper is to describe the influence of aforementioned factors on epidermis structure and dysfunction which leads to clinical symptoms of atopic dermatitis.

keywords:

Structure and function of the epidermal barrier in patients with atopic dermatitis – treatment options. Part one

Jagoda Pelc , Magdalena Czarnecka-Operacz , Zygmunt Adamski

atopic dermatitis, epidermal barrier, filaggrin, cytokines

Jagoda Pelc

,

Magdalena Czarnecka-Operacz

,

Zygmunt Adamski