Successful treatment of infliximab-induced psoriasiform skin lesions despite biologic therapy intensification in a paediatric patient with Crohn’s disease and primary sclerosing cholangitis
Agata Wasilewska
1
,
Małgorzata Chmielowska-Trybek
1
,
Małgorzata Sładek
1
Department of Paediatrics, Gastroenterology and Nutrition, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
Wasilewska A, Chmielowska-Trybek M, Sładek M. Successful treatment of infliximab-induced psoriasiform skin lesions despite biologic therapy intensification in a paediatric patient with Crohn’s disease and primary sclerosing cholangitis. Pediatria Polska - Polish Journal of Paediatrics. 2021;96(2):143-147. doi:10.5114/polp.2021.107400.
APA
Wasilewska, A., Chmielowska-Trybek, M., & Sładek, M. (2021). Successful treatment of infliximab-induced psoriasiform skin lesions despite biologic therapy intensification in a paediatric patient with Crohn’s disease and primary sclerosing cholangitis. Pediatria Polska - Polish Journal of Paediatrics, 96(2), 143-147. https://doi.org/10.5114/polp.2021.107400
Chicago
Wasilewska, Agata, Małgorzata Chmielowska-Trybek, and Małgorzata Sładek. 2021. "Successful treatment of infliximab-induced psoriasiform skin lesions despite biologic therapy intensification in a paediatric patient with Crohn’s disease and primary sclerosing cholangitis". Pediatria Polska - Polish Journal of Paediatrics 96 (2): 143-147. doi:10.5114/polp.2021.107400.
Harvard
Wasilewska, A., Chmielowska-Trybek, M., and Sładek, M. (2021). Successful treatment of infliximab-induced psoriasiform skin lesions despite biologic therapy intensification in a paediatric patient with Crohn’s disease and primary sclerosing cholangitis. Pediatria Polska - Polish Journal of Paediatrics, 96(2), pp.143-147. https://doi.org/10.5114/polp.2021.107400
MLA
Wasilewska, Agata et al. "Successful treatment of infliximab-induced psoriasiform skin lesions despite biologic therapy intensification in a paediatric patient with Crohn’s disease and primary sclerosing cholangitis." Pediatria Polska - Polish Journal of Paediatrics, vol. 96, no. 2, 2021, pp. 143-147. doi:10.5114/polp.2021.107400.
Vancouver
Wasilewska A, Chmielowska-Trybek M, Sładek M. Successful treatment of infliximab-induced psoriasiform skin lesions despite biologic therapy intensification in a paediatric patient with Crohn’s disease and primary sclerosing cholangitis. Pediatria Polska - Polish Journal of Paediatrics. 2021;96(2):143-147. doi:10.5114/polp.2021.107400.
Therapy with infliximab (IFX), a tumour necrosis factor-α (TNF-α) inhibitor, has been demonstrated to be highly effective in several immune-mediated inflammatory diseases including Crohn’s disease (CD) and psoriasis, both in adult and paediatric patients. With the increasingly widespread use and longer follow-up of IFX, one unexpected adverse effect that has been reported is the occurrence of psoriasis-like lesions, mainly during the maintenance therapy. The present report was aimed at describing a new case of IFX-induced psoriasis-like lesions in a 17-year-old boy with CD and primary sclerosing cholangitis (PSC), which was successfully treated with topical agents, despite IFX therapy intensification due to loss of the clinical response.
