en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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3/2019
vol. 57
 
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abstract:
Case report

Symptomatic multifocal avascular necrosis in an adolescent with neuropsychiatric systemic lupus erythematosus

Rabia Miray Kisla Ekinci
1
,
Sibel Balcı
1
,
Gonca Celik
2
,
Dilek Dogruel
3
,
Derya Ufuk Altintas
3
,
Mustafa Yilmaz
1

1.
Department of Pediatric Rheumatology, Cukurova University Faculty of Medicine, Adana, Turkey
2.
Department of Child and Adolescent Psychiatry, Cukurova University Faculty of Medicine, Adana, Turkey
3.
Department of Pediatric Allergy and Immunology, Cukurova University Faculty of Medicine, Adana, Turkey
Reumatologia 2019; 57, 3: 182–187
Online publish date: 2019/06/28
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Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by malar rash, oral ulcers, arthralgia, photosensitivity and nephritis. Herein, we report a rare comorbidity, multiple avascular necrosis (AVN), in an adolescent SLE patient and also highlight the importance of risk factors for this comorbidity with a brief literature review.

A 13-year-old female patient was admitted with severe headache, visual plus auditory hallucinations, polyarthritis and a history of recurrent oral ulcers. Acneiform malar rash, arthritis, cytopenia, low complement levels and autoantibody positivity yielded SLE diagnosis. We diagnosed her as having multifocal AVN after the 4th dose of cyclophosphamide, with bilateral knee pain and swelling and typical geographical lesions on magnetic resonance imaging.

Avascular necrosis is a rare comorbidity of SLE and neuropsychiatric involvement, cyclophosphamide administration and severe disease may be the possible risk factors in addition to corticosteroid use. Further multicenter studies investigating the possible risk factors of AVN with a large number of patients are needed.
keywords:

avascular necrosis of bone, adolescent, osteonecrosis, systemic lupus erythematosus







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