eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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SCImago Journal & Country Rank
 
4/2019
vol. 57
 
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abstract:
Review paper

Systemic sclerosis – multidisciplinary disease: clinical features and treatment

Piotr Sobolewski
1
,
Maria Maślińska
2
,
Marta Wieczorek
1
,
Zuzanna Łagun
1
,
Aleksandra Malewska
1
,
Marek Roszkiewicz
1
,
Raman Nitskovich
3
,
Elżbieta Szymańska
1
,
Irena Walecka
1

1.
Clinic of Dermatology, Centre of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of the Interior, Warsaw, Poland
2.
Clinic of Early Arthritis, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
3.
Medical University of Warsaw, Poland
Reumatologia 2019; 57, 4: 221-233
Online publish date: 2019/08/31
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Systemic sclerosis is a chronic autoimmune disease of still not fully understood pathogenesis. Fibrosis, vascular wall damage, and disturbances of innate and acquired immune responses with autoantibody production are prominent features. Systemic sclerosis has specific subsets with different autoantibodies, and differences in the affected skin areas. The suspicion of systemic sclerosis and establishing the diagnosis will be facilitated by the criteria created by EULAR/ACR experts. The treatment of this autoimmune disease remains a challenge for clinicians and new therapeutic options are constantly sought. The occurrence of various symptoms and the involvement of many organs and systems make systemic sclerosis a multidisciplinary disease and require a holistic approach. The present article summarizes different clinical features of systemic sclerosis and the profile of autoantibodies and discusses recent rules and future perspectives in disease management.
keywords:

systemic sclerosis, fibrosis, new therapies






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