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ISSN: 1233-9687
Polish Journal of Pathology
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vol. 70
Letter to the Editor

TC2 C776G polymorphism and oral cancer

Won Sriwijitalai
Viroj Wiwanitkit

RVT Medical Academic Center, Bangkok Thailand
Adjunct professor, Joseph Ayobabalola University, Ikeji-Arakeji, Nigeria
Pol J Pathol 2019; 70 (3): 223-223
Online publish date: 2019/12/07
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Dear Editor
We read the publication on “TC2 C776G polymorphism studies in patients with oral cancer in the Polish population” with a great interest [1]. Malinowska et al. studied on polymorphism of transcobalamine 2 gene and concluded that “our population G/G homozygosity of C776G TC2 gene polymorphism increases the risk of oral cancer [1]” and “Regarding C/G genotype of the C776G TC2 gene, polymorphism also increases the risk of developing this cancer [1].” The results in this report are concordant with the previous report on this polymorphism and and head and neck squamous cell carcinoma risk [2]. A possible explanation for the observation might be due to the molecular change due to the G to C mutations. If we considered the molecular weight change based on molecular calculation at the mutation site, G776C, the change G to C is equal to +36.03 g/Mol (75.07 to 111.1). The increased molecular weight due to genetic change can imply a requirement of more molecules for completeness of final expression. This means an increased risk for carcinogenesis. It is the same biological process as described in in other malignancies [3, 4].
The authors declare no conflict of interest.


Malinowska K, Morawiec-Sztandera A, Majsterek I, Kaczmarczyk D. TC2 C776G polymorphism studies in patients with oral cancer in the Polish population. Pol J Pathol 2016; 67: 277-282.
da Silva LM, Galbiatti AL, Ruiz MT, et al. MTHFD1 G1958A, BHMT G742A, TC2 C776G and TC2 A67G polymorphisms and head and neck squamous cell carcinoma risk. Mol Biol Rep 2012; 39: 887-893.
Joob B, Wiwanitkit V. Interleukin-2-330T/G and Interleukin-10-1082A/G Genetic Polymorphisms and B-Cell Non-Hodgkin Lymphoma. Turk J Haematol 2018; 35: 301-302.
Sookaromdee P, Wiwanitkit V. Wilms Tumor-1 (WT1) rs16754 Polymorphism. Turk J Haematol. 2019; 36: 69-69.
Copyright: © 2019 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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