eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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1/2020
vol. 16
 
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abstract:
Systematic review/Meta-analysis

The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis

Jian-Long Miao
1
,
Jin-Hua Zhou
1
,
Jing-Jing Cai
1
,
Rui-Juan Liu
1

1.
Department of Respiratory Medicine, Shandong Jining No. 1 People’s Hospital, Jining, Shandong, China
Arch Med Sci 2020; 16 (1): 16–26
Online publish date: 2019/12/31
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Introduction
Identifying target oncogenic alterations in lung cancer represents a major development in disease management. We examined the association of fibroblast growth factor receptor 1 (FGFR1) gene amplification with pathological characteristics and geographic region.

Material and methods
We conducted a meta-analysis of studies published between January 2010 and October 2016. Relative risks (RR) and corresponding 95% confidence intervals (CI) were calculated regarding the rate of FGFR1 amplification in different lung cancer types and geographic region.

Results
Twenty-three studies (5252 patients) were included. There was heterogeneity between studies. However, in subgroup analyses for squamous cell carcinoma (SCC), small cell lung cancer (SCLC), studies using the same definition of FGFR1 amplification, and those from Australia, no significant heterogeneity was detected. The prevalence of FGFR1 amplification in these studies ranged from 4.9% to 49.2% in non-small cell lung cancer (NSCLC), 5.1% to 41.5% in SCC, 0% to 14.7% in adenocarcinoma, and 0% to 7.8% in SCLC. The prevalence of FGFR1 amplification was significantly higher in SCC than in adenocarcinoma (RR = 5.2) and SCLC (RR = 4.2). The prevalence of FGFR1 amplification ranged from 5.6% to 22.2% in Europe, 4.1% to 18.2% in the United States, 7.8% to 49.2% in Asia, and 14.2% to 18.6% in Australia. The rate of FGFR1 amplification was higher in Asians than in non-Asians (RR = 1.9) in NSCLC.

Conclusions
These results suggest that FGFR1 amplification occurs more frequently in SCC and in Asians. FGFR1 amplification may be a potential new therapeutic target for specific patients and lung cancer subtypes.

keywords:

fibroblast growth factor receptor 1, gene amplification, lung cancer

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