The association between metabolic syndrome and vitiligo: a systematic review

Aleksandra Białczyk; Barbara Kamińska; Rafał Czajkowski

doi:10.5114/ada.2025.149438

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

The association between metabolic syndrome and vitiligo: a systematic review

Aleksandra Białczyk

¹

,

Barbara Kamińska

¹

,

Rafał Czajkowski

¹

Department of Dermatology and Venereology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland

Adv Dermatol Allergol 2025; XLII (2): 134-142

DOI: https://doi.org/10.5114/ada.2025.149438

Online publish date: 2025/04/15

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Vitiligo is a chronic autoimmune disorder linked to systemic inflammation, oxidative stress, and metabolic dysregulation, including metabolic syndrome (MetS). This review examines the shared mechanisms underlying vitiligo and MetS, highlighting oxidative stress, pro-inflammatory cytokines, and lipid dysregulation as central contributors. A systematic analysis of 23 studies found association between vitiligo and MetS, though variations exist based on the disease type, severity, and duration. Emerging therapies, such as statins and thiazolidinediones demonstrate potential for managing vitiligo and its metabolic risks by targeting oxidative and inflammatory pathways. While animal and in vitro studies show promise, clinical outcomes are inconsistent, with safety concerns limiting systemic treatments.

keywords:

The association between metabolic syndrome and vitiligo: a systematic review

Aleksandra Białczyk 1 , Barbara Kamińska 1 , Rafał Czajkowski 1

vitiligo, metabolic syndrome, statins, thiazolidinediones

Aleksandra Białczyk

¹

,

Barbara Kamińska

¹

,

Rafał Czajkowski

¹