The association of HLA-C and ERAP1 polymorphisms
in early and late onset psoriasis and psoriatic arthritis
patients of Hungary

László Képíró; Márta Széll; László Kovács; Péter Keszthelyi; Lajos Kemény; Rolland Gyulai

doi:10.5114/ada.2021.104277

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

The association of HLA-C and ERAP1 polymorphisms in early and late onset psoriasis and psoriatic arthritis patients of Hungary

László Képíró

¹

,

Márta Széll

^{2, 3}

,

László Kovács

⁴

,

Péter Keszthelyi

⁵

,

Lajos Kemény

^{1, 2}

,

Rolland Gyulai

^{1, 6}

Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary

MTA-SZTE Dermatological Research Group, University of Szeged, Szeged, Hungary

Department of Medical Genetics, University of Szeged, Szeged, Hungary

Department of Rheumatology, University of Szeged, Szeged, Hungary

Department of Rheumatology, Pándy Kálmán Békés County Hospital, Gyula, Hungary

Department of Dermatology, Venereology and Oncodermatology, University of Pécs, Pécs, Hungary

Adv Dermatol Allergol 2021; XXXVIII (1): 43-51

DOI: https://doi.org/10.5114/ada.2021.104277

Online publish date: 2021/03/10

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AMA

Képíró L, Széll M, Kovács L, Keszthelyi P, Kemény L, Gyulai R. The association of HLA-C and ERAP1 polymorphisms
in early and late onset psoriasis and psoriatic arthritis
patients of Hungary. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(1):43-51. doi:10.5114/ada.2021.104277.

APA

Képíró, L., Széll, M., Kovács, L., Keszthelyi, P., Kemény, L.,  & Gyulai, R. (2021). The association of HLA-C and ERAP1 polymorphisms
in early and late onset psoriasis and psoriatic arthritis
patients of Hungary. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(1), 43-51. https://doi.org/10.5114/ada.2021.104277

Chicago

Képíró, László, Márta Széll, László Kovács, Péter Keszthelyi, Lajos Kemény,  and Rolland Gyulai. 2021. "The association of HLA-C and ERAP1 polymorphisms
in early and late onset psoriasis and psoriatic arthritis
patients of Hungary". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 38 (1): 43-51. doi:10.5114/ada.2021.104277.

Harvard

Képíró, L., Széll, M., Kovács, L., Keszthelyi, P., Kemény, L.,  and Gyulai, R. (2021). The association of HLA-C and ERAP1 polymorphisms
in early and late onset psoriasis and psoriatic arthritis
patients of Hungary. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(1), pp.43-51. https://doi.org/10.5114/ada.2021.104277

MLA

Képíró, László et al. "The association of HLA-C and ERAP1 polymorphisms
in early and late onset psoriasis and psoriatic arthritis
patients of Hungary." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 38, no. 1, 2021, pp. 43-51. doi:10.5114/ada.2021.104277.

Vancouver

Képíró L, Széll M, Kovács L, Keszthelyi P, Kemény L, Gyulai R. The association of HLA-C and ERAP1 polymorphisms
in early and late onset psoriasis and psoriatic arthritis
patients of Hungary. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(1):43-51. doi:10.5114/ada.2021.104277.

Introduction
Single nucleotide polymorphisms (SNPs) of the HLA-C and ERAP1 genes were recently determined to contribute to psoriasis susceptibility. However, data regarding the association of these genes with specific subgroups of psoriasis are scarce. Aim: To examine the possible association of the HLA-C and ERAP-1 polymorphisms with early and late onset psoriasis and psoriatic arthritis.

Material and methods
Five ERAP1 SNPs and two HLA-C SNPs were genotyped in 105 psoriatic arthritis patients, 214 cutaneous psoriasis patients and 200 healthy individuals. Haplotypes were constructed for three ERAP1 SNPs (rs17482078, rs10050860, rs30187), and interaction between HLA-Cw*0602 and ERAP1 was also analysed.

Results
The HLA-Cw*0602 rs10484554 SNP was found to be a strong susceptibility factor for early onset cutaneous psoriasis and early onset psoriatic arthritis. ERAP1 SNPs (rs10050860, rs17482078, rs27525) appear to have a protective function for early onset psoriatic arthritis. The haplotype B was identified as a susceptibility factor for late onset psoriatic arthritis. In HLA-C positive individuals the rs27524 ERAP1 SNP was associated with a significantly increased risk of psoriatic arthritis development, whereas the rs27525 ERAP1 SNP had the opposite effect.

Conclusions
These results suggest that the HLA-C and ERAP1 genes contribute to the pathogenesis of psoriasis and psoriatic arthritis in an age-dependent manner.

keywords:

The association of HLA-C and ERAP1 polymorphisms in early and late onset psoriasis and psoriatic arthritis patients of Hungary

László Képíró 1 , Márta Széll 2, 3 , László Kovács 4 , Péter Keszthelyi 5 , Lajos Kemény 1, 2 , Rolland Gyulai 1, 6

HLA-C, ERAP1, psoriasis, psoriatic arthritis, polymorphism

László Képíró

¹

,

Márta Széll

^{2, 3}

,

László Kovács

⁴

,

Péter Keszthelyi

⁵

,

Lajos Kemény

^{1, 2}

,

Rolland Gyulai

^{1, 6}