eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
1/2021
vol. 38
 
Share:
Share:
more
 
 
abstract:
Original paper

The association of HLA-C and ERAP1 polymorphisms in early and late onset psoriasis and psoriatic arthritis patients of Hungary

László Képíró
1
,
Márta Széll
2, 3
,
László Kovács
4
,
Péter Keszthelyi
5
,
Lajos Kemény
1, 2
,
Rolland Gyulai
1, 6

1.
Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary
2.
MTA-SZTE Dermatological Research Group, University of Szeged, Szeged, Hungary
3.
Department of Medical Genetics, University of Szeged, Szeged, Hungary
4.
Department of Rheumatology, University of Szeged, Szeged, Hungary
5.
Department of Rheumatology, Pándy Kálmán Békés County Hospital, Gyula, Hungary
6.
Department of Dermatology, Venereology and Oncodermatology, University of Pécs, Pécs, Hungary
Adv Dermatol Allergol 2021; XXXVIII (1): 43-51
Online publish date: 2021/03/10
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Single nucleotide polymorphisms (SNPs) of the HLA-C and ERAP1 genes were recently determined to contribute to psoriasis susceptibility. However, data regarding the association of these genes with specific subgroups of psoriasis are scarce. Aim: To examine the possible association of the HLA-C and ERAP-1 polymorphisms with early and late onset psoriasis and psoriatic arthritis.

Material and methods
Five ERAP1 SNPs and two HLA-C SNPs were genotyped in 105 psoriatic arthritis patients, 214 cutaneous psoriasis patients and 200 healthy individuals. Haplotypes were constructed for three ERAP1 SNPs (rs17482078, rs10050860, rs30187), and interaction between HLA-Cw*0602 and ERAP1 was also analysed.

Results
The HLA-Cw*0602 rs10484554 SNP was found to be a strong susceptibility factor for early onset cutaneous psoriasis and early onset psoriatic arthritis. ERAP1 SNPs (rs10050860, rs17482078, rs27525) appear to have a protective function for early onset psoriatic arthritis. The haplotype B was identified as a susceptibility factor for late onset psoriatic arthritis. In HLA-C positive individuals the rs27524 ERAP1 SNP was associated with a significantly increased risk of psoriatic arthritis development, whereas the rs27525 ERAP1 SNP had the opposite effect.

Conclusions
These results suggest that the HLA-C and ERAP1 genes contribute to the pathogenesis of psoriasis and psoriatic arthritis in an age-dependent manner.

keywords:

HLA-C, ERAP1, psoriasis, psoriatic arthritis, polymorphism

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe