ISSN: 2451-0629
Archives of Medical Science - Atherosclerotic Diseases
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Official journal of the International Lipid Expert Panel (ILEP)
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abstract:
Clinical research

The correlation between sarcopaenia and post-transjugular intrahepatic portosystemic shunt hepatic encephalopathy: a single-institution review

Zahava C. Farkas
,
Tariq Rashid
,
Ying Sharon Chen
,
Tausif Mohamed Siddiqui
,
Srikanth Yandrapalli
,
Shalom Frager
,
Wilbert S. Aronow
,
Roxana Bodin
,
Shekher Maddineni

Arch Med Sci Atheroscler Dis 2019; 4: e89–e93
Online publish date: 2019/05/27
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Introduction
Sarcopaenia, or muscle wasting, can be used to objectively quantify malnutrition in cirrhotic patients.

Material and methods
In this retrospective study, a list of all patients who underwent transjugular intrahepatic portosystemic shunt (TIPS) procedure at Westchester Medical Centre from September 2009 to July 2018 was obtained, and individual chart reviews were performed.

Results
In total, 90 charts were reviewed. Fifty-six patients satisfied our inclusion criteria. Using PMA cut-off values determined in prior studies, we found that 50 of the 56 patients in our study were sarcopaenic. The majority of the patients were male (n = 45). The most common aetiology of cirrhosis was alcoholic cirrhosis (n = 27), followed by viral hepatitis (n = 10), and the most common indication for TIPS was refractory ascites (n = 34). The mean age in the sarcopaenic group was 60.1 years compared to 57.4 years in the non-sarcopaenic group. Mean MELD-Na scores and albumin levels were comparable in both groups. Only one patient was deceased at 6 months post-TIPS. Of the 56 patients included, 18 developed clinically significant hepatic encephalopathy within 6 months of their TIPS procedure. All 18 patients belonged to the sarcopaenic group; 6 patients were not sarcopaenic, and none of them were noted to develop HE within 6 months of their TIPS (p = 0.074)

Conclusions
Based on our results, we concluded that sarcopaenia correlates with the development of hepatic encephalopathy within 6 months of a TIPS procedure; however, the results did not reach statistical significance.

keywords:

sarcopaenia, cirrhosis, transjugular intrahepatic portosystemic shunt

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