Abstract
The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases
- Department of Pediatric Allergy and Immunology, Umraniye Training and Research Hospital, Istanbul, Türkiye
- Department of Paediatric Radiology, University of Health Sciences, Umraniye Training and Research Hospital, Umraniye, Istanbul, Türkiye
- Maltepe District Health Directorate, Istanbul, Türkiye
- Department of Public Health, International School of Medicine, Istanbul Medipol University, Istanbul, Türkiye
Introduction:
An impaired skin barrier has been reported in allergic diseases.
Aim:
In this study, we aimed to evaluate dermis thickness in children with house dust allergy without skin symptoms.
Material and methods:
This cross-sectional study included children aged 4–18 years with asthma and/or allergic rhinitis. Participants were divided into three groups: healthy controls (n = 50), patients sensitized to house dust mites (n = 60), and patients with negative house dust mite tests (n = 48). The thickness of the dermis layers of the skin was measured at the cubital fossa using an ultrasound.
Results:
The median age and gender distribution were similar across the house dust mite-positive and -negative groups and the healthy control group. There was no significant difference between the groups in terms of dermis thickness (p = 0.053). Absolute eosinophils and eosinophil percentage were significantly negatively correlated with dermis (p < 0.05). There was no significant correlation between total IgE, house dust mite specific IgE and skin test values and skin thickness (p > 0.05).
Conclusions:
The findings of this study highlight the impact of house dust mite sensitization on skin thickness, offering potential contributions to the management and treatment strategies of allergic diseases.
>Keywords
house dust mite sensitization, skin barrier, skin thickness, children, allergy
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