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ISSN: 0034-6233
Reumatologia/Rheumatology
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5/2009
vol. 47
 
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abstract:
Original paper

The effect of increasing amounts of synovial fluid isolated from patients with rheumatoid arthritis on the respiratory burst of human neutrophils

Michał Gajewski
,
Szymon Szczepanik
,
Łukasz Wysocki
,
Wojciech Dziewczopolski
,
Joanna Gajewska
,
Sławomir Maśliński

Reumatologia 2009; 47, 5: 273-281
Online publish date: 2009/12/29
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It has been proposed that the inappropriate release of oxidants and proteolytic enzymes from activated neutrophils is responsible for joint damage observed in rheumatoid arthritis (RA). The present study examines the effect of increasing concentrations of synovial fluid [SF] (0-80%) on the oxidative response of neutrophils isolated from SF of RA patients and the blood of healthy subjects. To reflect better the real conditions of the inflamed joint we used in our experiments higher concentrations of SF than was previously reported. We found that increasing the concentrations of SF has a different effect on lucigenin-dependent and luminol-dependent CL response.
keywords:

reumatoidalne zapalenie stawów, neutrofile, chemiluminescencja, płyn stawowy







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