Advances in Dermatology and Allergology
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ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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2/2026
vol. 43
 
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Original paper

The effect of omalizumab treatment on inflammatory parameters in urticarial diseases: a retrospective study

Kubra Aydogan Temizel
1
,
Pinar Dursun
1
,
Guliz Ikizoglu
1

  1. Department of Dermatology, Faculty of Medicine, Mersin University, Mersin, Turkey
Adv Dermatol Allergol 2026; XLIII (2): 138–143
Online publish date: 2026/04/09
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1. Hennino A, Bérard F, Guillot I, et al. Pathophysiology of urticaria. Clin Rev Allergy Immunol 2006; 30: 3-11.
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3. Goncu EK, Aktan S, Atakan N, et al. [Turkish guideline for the diagnosis and treatment of urticaria – 2016]. Turkderm Arch Turk Dermatol Venereol 2016; 50: 82-98.
4. Kolkhir P, Giménez-Arnau AM, Kulthanan K, et al. Urticaria. Nat Rev Dis Primers 2022; 8: 61.
5. Marzano AV, Maronese CA, Genovese G, et al. Urticarial vasculitis: clinical and laboratory findings with a particular emphasis on differential diagnosis. J Allergy Clin Immunol 2022; 149: 1137-49.
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8. Asero R, Marzano AV, Ferrucci S, et al. D-dimer plasma levels parallel the clinical response to omalizumab in patients with severe chronic spontaneous urticaria. Int Arch Allergy Immunol 2017; 172: 40-4.
9. Hon KL, Leung AKC, Ng WGG, et al. Chronic urticaria: an overview of treatment and recent patents. Recent Pat Inflamm Allergy Drug Discov 2019; 13: 27-37.
10. Onder S, Ozturk M. How does omalizumab affect the immunoinflammatory response in patients with chronic spontaneous urticaria? Cutan Ocul Toxicol 2020; 39: 31-5.
11. Gokcek GE, Solak EO, Colgecen E. The effect of omalizumab treatment on hematological inflammatory parameters and immunoglobulin E levels in patients with chronic spontaneous urticaria. Turk J Dermatol 2021; 15: 95-101.
12. Kolkhir P, Altrichter S, Hawro T, et al. C-reactive protein is linked to disease activity, impact, and response to treatment in patients with chronic spontaneous urticaria. Allergy 2018; 73: 940-8.
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14. Kaplan AP, Giménez-Arnau AM, Saini SS. Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria. Allergy 2017; 72: 519-33.
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18. Ertas R, Ozyurt K, Karakukcu C, et al. Evaluation of platelet parameters and neutrophil/lymphocyte ratio during omalizumab treatment in patients with severe chronic spontaneous urticaria. Turk J Med Sci 2018; 48: 1255-62.
19. Rifaioglu EN, Bulbul Sen B, Ekiz O, et al. Neutrophil to lymphocyte ratio in Behçet’s disease as a marker of disease activity. Acta Dermatovenerol Alp Pannonica Adriat 2014; 23: 65-7.
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23. Tamer F. Omalizumab does not lead to a distinct alteration in hematological parameters and complete blood count-derived inflammation biomarkers except for basophil count. Cutan Ocul Toxicol 2020; 39: 229-32.
24. Xu XR, Zhang D, Oswald BE, et al. Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond. Crit Rev Clin Lab Sci 2016; 53: 409-30.
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27. Chandrashekar L, Rajappa M, Sundar I, et al. Platelet activation in chronic urticaria and its correlation with disease severity. Platelets 2014; 25: 162-5.
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29. Akdogan N, Demirel Ogut N, Gogan S, Atakan N. Long-term effects of omalizumab on peripheral blood cells and C-reactive protein levels in patients with chronic spontaneous urticaria. Dermatol Ther 2019; 32: e12966.
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