eISSN: 1731-2531
ISSN: 1642-5758
Anaesthesiology Intensive Therapy
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1/2022
vol. 54
 
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abstract:
Original article

The effect of ultrasound-guided serratus plane block on the quality of life in patients undergoing modified radical mastectomy and axillary lymph node dissection: a randomized controlled study

Muhammet M. Sulak
1
,
Ali Ahiskalioglu
1, 2
,
Ahmet M. Yayik
1, 2
,
Erdem Karadeniz
3
,
Mine Celik
1, 2
,
Ufuk Demir
1
,
Muhammet A. Ari
1
,
Haci A. Alici
4

1.
Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey
2.
Clinical Research, Development and Design Application and Research Center, Ataturk University School of Medicine, Erzurum, Turkey
3.
Department of General Surgery, Ataturk University School of Medicine, Erzurum, Turkey
4.
Department of Anesthesiology, Medipol University Faculty of Medicine, Istanbul, Turkey
Anaesthesiol Intensive Ther 2022; 54, 1: 48–55
Online publish date: 2022/03/06
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Background
Modified radical mastectomy (MRM) and axillary lymph node dissection (AD) are the most commonly used surgical methods in breast cancer surgery, and they are characterized by moderate to severe pain. This study aimed to investigate the effect of ultrasound-guided serratus plane block (SPB) on postoperative acute and chronic pain in patients undergoing MRM and AD.

Methods
After ethical approval, 60 patients, aged between 18–65 years, ASA I–III, underwent unilateral MRM, and AD was assigned into 2 groups. The SPB group received ultrasound-guided SPB with 30 mL 0.25% bupivacaine, and the control group received 2 mL saline injection subcutaneously. Postoperative analgesia was performed with intravenous patient-controlled analgesia and dexketoprofen trometamol. Pain scores, opioid consumption, and rescue analgesic requirements were recorded. Chronic pain and quality of life were evaluated with the Numerical Rating Scale (NRS), short form-36 (SF-36), and painDETECT.

Results
Compared with the control group, the visual analogue scale scores were statistically lower in the SPB group during 4 postoperative hours in post-anaesthetic care unit PACU at 1st, 2nd (P < 0.001), and 4th hour (P = 0.014). Fentanyl consumption and rescue analgesics were lower in the SPB group than in the control group (0–4 h, P = 0.001; 4–8 h, 8–12 h, 24 h; total P < 0.001). The incidence of chronic pain was 11%, and there was no statistically significant difference between control and SPB groups in terms of SF-36, NRS, and painDETECT scores measured at the first and sixth months.

Conclusions
SPB demonstrated superiority versus the control group concerning acute postoperative pain parameters. However, SPB had no influence on the quality of life and did not prevent chronic postmastectomy pain.

keywords:

modified radical mastectomy, serratus plan block, chronic pain, pre-emptive analgesia

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