eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
Current issue Archive Manuscripts accepted About the journal Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
2/2018
vol. 14
 
Share:
Share:
more
 
 
abstract:
Clinical research

The impact of age, sex, blepharitis, rosacea and rheumatoid arthritis on Demodex mite infection

Aleksandra Sędzikowska, Maciej Osęka, Piotr Skopiński

Arch Med Sci 2018; 14, 2: 353–356
Online publish date: 2016/06/17
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction: Two human-specific Demodex species have been described: Demodex folliculorum and Demodex brevis. A medical condition caused by the presence of Demodex is called demodicosis.

Material and methods: The study material comprised eyelashes collected from 1499 patients.

Results: Demodex sp. infection was revealed in 47% of patients (487 women and 216 men). We determined the following rates of infection by age groups: 1–25 (8% of infected subjects), 26–40 (36%), 41–55 (50%), 56–70 (67%), over 70 (77%). The sex of the subjects was not identified as a factor conducive to infection (p = 0.108), while their age was positively correlated with the risk of infection (p < 0.005). The 1499 study subjects included patients with blepharitis, rosacea, and rheumatoid arthritis. The study investigated the extent to which the above-mentioned conditions affect the risk of Demodex infection. Applying the method of logistic regression, the infection probability was estimated, depending on the age, sex, and comorbidities such as blepharitis, rosacea, and rheumatoid arthritis. Patients suffering from blepharitis were found to have a nearly 2.5-fold higher risk of Demodex infection than those without blepharitis, and the risk for rosacea patients was determined as three-fold higher than that of the general population.

Conclusions: Blepharitis and rosacea are risk factors for Demodex infection.
keywords:

demodicosis, risk factor, epidemiology

references:
Desch C, Nutting WB. Demodex folliculorum (Simons) and D. brevis Akbulatova of man: redescription and reevaluation. J Parasitol 1972; 58: 169-77.
Coston TO. Demodex folliculorum blepharitis. Trans Am Ophthalmol Soc 1967; 65: 361-92.
Ivy SP, Mackall CL, Gore L, Gress RE, Hartley AH. Demodicidosis in childhood acute lymphoblastic leukemia: an opportunistic infection occurring with immunosuppression. J Pediatr 1995; 127: 751-4.
Patrizi A, Neri I, Chieregato C, Misciali M. Demodicidosis in immunocompetent young children: report of eight cases. Dermatology 1997; 195: 239-42.
Herron MD, O’Reilly MA, Vanderhooft SL. Refractory Demodex folliculitis in five children with acute lymphoblastic leukemia. Pediatr Dermatol 2005; 22: 407-11.
Wesolowska M, Knysz B, Reich A, et al. Prevalence of Demodex spp. in eyelash follicles in different populations. Arch Med Sci 2014; 10: 319-24.
Roihu T, Kariniemi AL. Demodex mites in acne rosacea. J Cutan Pathol 1998; 2: 550-2.
El-Shazly AM, Ghaneum BM, Morsy TA, Aaty HE. The pathogenesis of Demodex folliculorum (hair follicular mites) in females with and without rosacea. J Egypt Soc Parasitol 2001; 31: 867-75.
Chen W, Plewig G. Are Demodex mites principal, conspirator, accomplice, witness or bystander in the cause of rosacea? Am J Clin Dermatol 2015; 16: 67-72.
Forton F, Song M. Limitations of standardized skin surface biopsy in measurement of the density of Demodex folliculorum. A case report. Br J Dermatol 1998; 139: 697-700.
Aşkin U, Seçkin D. Comparison of the two techniques for measurement of the density of Demodex folliculorum: standardized skin surface biopsy and direct microscopic examination. Br J Dermatol 2010; 162: 1124-6.
de Rojas M, Riazzo C, Callejón R, Guevara D, Cutillas C. Morphobiometrical and molecular study of two populations of Demodex folliculorum from humans. Parasitol Res 2012; 110: 227-33.
Zhao YE, Ma JX, Hu L, Wu LP, De Rojas M. Discrimination between Demodex folliculorum (Acari: Demodicidae) isolates from China and Spain based on mitochondrial cox1 sequences. J Zhejiang Univ Sci B 2013; 14: 829-36.
Criado-Fornelio A, Heredero-Bermejo I, Pérez-Serrano J. Alternative mounting media for preservation of some protozoa. J Microbiol Methods 2014; 105: 146-9.
Szumilas M. Explaining odds ratios. J Can Acad Child Adolesc Psychiatry 2010; 19: 227-9.
Aycan OM, Otlu GH, Karaman U, Daldal N, Atambay M. Frequency of the appearance of Demodex sp. in various patient and age groups. Turkiye Parazitol Derg 2007; 31: 115-8.
Liu J, Sheha H, Tseng SC. Pathogenic role of Demodex mites in blepharitis. Curr Opin Allergy Clin Immunol 2010; 10: 505-10.
Lee SH, Chun YS, Kim JH, Kim ES, Kim JC. The relationship between Demodex and ocular discomfort. Invest Ophthalmol Vis Sci 2010; 51: 2906-11.
Lacey N, Kavanagh K, Tseng SC. Under the lash: Demodex mites in human diseases. Biochem (Lond) 2009; 31: 2-6.
Dhingra KK, Saroha V, Gupta P, Khurana N. Demodex-associated dermatologic conditions – a coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma. Pathol Res Pract 2009; 205: 423-6.
Zhao YE, Peng Y, Wang XL, et al. Facial dermatosis associated with Demodex: a case-control study. J Zhejiang Univ Sci B 2011; 12: 1008-15.
Ciftci IH, Dundar U, Cetinkaya Z, et al. Demodex folliculorum in patients with rheumatoid arthritis. Acta Parasitol 2007; 52: 70-3.
Forton F, Seys B. Density of Demodex folliculorum in rosacea: a case-control study using standardized skin-surface biopsy. Br J Dermatol 1993; 128: 650-9.
Gao YY, Xu DL, Huang IJ, Wang R, Tseng SC. Treatment of ocular itching associated with ocular demodicosis by 5% tea tree oil ointment. Cornea 2012; 31: 14-7.
Sędzikowska A, Osęka M, Roman B, Jaremko E. Impact of Salvia and peppermint oil on the in vitro survival of Demodex mites. J Bacteriol Parasitol 2015; 6: 1-2.
FEATURED PRODUCTS
Quick links
© 2018 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe