eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
5/2012
vol. 16
 
Share:
Share:
abstract:
Original paper

The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9%

Agnieszka Karbownik
,
Edyta Szałek
,
Hanna Urjasz
,
Aleksandra Głęboka
,
Emilia Mierzwa
,
Edmund Grześkowiak

Wspolczesna Onkol 2012; 16 (5): 435–439
Online publish date: 2012/11/20
View full text Get citation
 
PlumX metrics:
Aim of the study: The subject of study was the stability of cisplatin in concentrate in glass vials and diluted in polyethylene (PE) bags stored at 15–25°C for up to 30 days.

Material and methods: Original vials of cisplatin injection (1 mg/ml, Teva) were stored at room temperature and subjected to re-piercing after 1, 2, 3, 7, 14, 21, 28 and 30 days following the initial piercing. Cisplatin infusions at nominal concentrations of 0.1 mg/ml were prepared in 0.9% sodium chloride (1000 ml) in PE bags. Chemical stability was measured by means of a stability-indicating high-performance liquid chromatography (HPLC) assay. Physical stability was assessed by visual inspection in normal light.

Results: The concentration of cisplatin at each sampling time in the analysed solutions remained within 92.0–100.7% of initial concentration, regardless of the container. No changes in colour or turbidity were observed in any of the vials or prepared solutions.

Conclusions: Cisplatin, both undiluted in glass containers and diluted with NaCl 0.9% in PE bags, remains stable (< 10% degradation) for at least 30 days at room temperature when protected from light.
keywords:

cisplatin, stability, concentrate, infusion

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.