ISSN: 2451-0637
Archives of Medical Science - Civilization Diseases
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1/2021
vol. 6
 
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abstract:
State of the art paper

The role of HMGB1 in gastrointestinal cancers

Nimet Yılmaz
1
,
Mustafa Yıldırım
2
,
Hanım Seval Savaş
3
,
Hülya Çiçek
3
,
Özlem Nuray Sever
4

1.
Department of Gastroenterology, Sanko University, Gaziantep, Turkey
2.
Department of Oncology, School of Medicine, Sanko University, Gaziantep, Turkey
3.
Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
4.
Department of Oncology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
Arch Med Sci Civil Dis 2021; 6: e1–e7
Online publish date: 2021/04/16
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Despite advances in diagnostic and therapeutic methods, gastrointestinal (GI) cancers have both a high incidence and a high mortality rate. In addition to surgery, chemotherapy and radiotherapy, novel modalities such as immunotherapy are increasingly used in the treatment of these cancers. However, the prognosis in GI cancers remains poor despite the availability of these treatments, which prompted the search for new prognostic and predictive markers. High-mobility group box-1 (HMGB1) is a non-histone DNA protein which is known as a nuclear transcription factor. The search for new therapeutic targets has also gained importance. In this review, the prognostic and predictive role of HMGB1 in gastrointestinal cancers will be discussed in light of current literature.
keywords:

gastrointestinal cancers, HMGB1, predictive markers, prognostic markers

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