eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2017
vol. 42
 
Share:
Share:
abstract:
Review paper

The role of anti-citrullinated protein antibodies (ACPA) in the pathogenesis of rheumatoid arthritis

Weronika Kurowska
,
Ewa H. Kuca-Warnawin
,
Anna Radzikowska
,
Włodzimierz Maśliński

(Centr Eur J Immunol 2017; 42 (4): 390-398)
Online publish date: 2017/12/30
View full text Get citation
 
PlumX metrics:
The most specific autoimmunity known for rheumatoid arthritis (RA) is reflected by generation

of anti-citrullinated protein antibodies (ACPA). Presence of ACPA in established RA is associated with disease severity, while generation of ACPA at early developmental phases of RA can have a strong predictive value for progressing to the full-blown disease. Hence, development of ACPA may be of crucial importance to the pathogenesis of RA. Therefore, a lot of effort has been put recently to investigate the feature of ACPA at early developmental stages of RA (before disease onset) and functional activities of these autoantibodies. Results of these studies enlarged the knowledge about the nature of ACPA, which is essential for planning the therapeutic or preventive strategies interfering with their development and pathogenic functions. In this review we describe recent evidence for a role of ACPA in the etiopathogenesis of RA and indicate key unresolved issues regarding ACPA biology that need to be clarified in the future.

keywords:

rheumatoid arthritis, pathogenesis, anti-citrullinated protein antibodies

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.