eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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abstract:
State of the art paper

The role of curcumin in liver diseases

Antonio Riccardo Buonomo
,
Riccardo Scotto
,
Salvatore Nappa
,
Michele Arcopinto
,
Andrea Salzano
,
Alberto Maria Marra
,
Roberta D’Assante
,
Emanuela Zappulo
,
Guglielmo Borgia
,
Ivan Gentile

Arch Med Sci
Online publish date: 2018/02/20
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Chronic liver diseases are a major medical problem worldwide. Despite the availability of etiologic-specific treatments for several liver diseases, no drug or medication is available for the regression of hepatic fibrosis and cirrhosis. Curcumin is a natural compound extractable from turmeric. Several studies have uncovered its role in the modulation of biological mechanisms involved in liver injury. The best known biological effect of curcumin is the interaction with different pathways involved in the development of liver fibrosis, as shown in both in vitro and in vivo models of chronic liver injury. In pre-clinical studies, curcumin was also effective in decreasing alcohol-, glucose- and hepatitis C virus (HCV)-related liver injury, as well as HCV replication in hepatocytes. These data make curcumin a potential therapeutic agent for regression of fibrosis and cirrhosis, especially in the setting of HCV infection that can be easily eradicated thanks to the availability of several direct-acting antivirals.
keywords:

curcumin, liver fibrosis, cirrhosis, hepatitis C virus, hepatocarcinoma

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