eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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4/2022
vol. 39
 
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abstract:
Review paper

The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus

Aleksandra Frątczak 
1
,
Karina Polak
1
,
Michał Szczepanek
1
,
Anna Lis-Święty
1

1.
Department of Dermatology, Medical University of Silesia, Katowice, Poland
Adv Dermatol Allergol 2022; XXXIX (4): 645-650
DOI: https://doi.org/10.5114/ada.2022.118919
Online publish date: 2022/09/01
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Inflammation and atherogenic dyslipidaemia are often observed in skin diseases and represent an increased risk of cardiovascular disorders. Proprotein convertase subtilisin/kexin type 9 plays an important role in the regulation of serum low-density lipoprotein cholesterol levels. Its biological role, however, seems to go much beyond the regulation of cholesterol metabolism. The article presents potential pathophysiological links between inflammatory process and lipid disorders based on the example of psoriasis and systemic lupus erythematosus.
keywords:

PCSK9, evolocumab, alirocumab, psoriasis, systemic lupus erythematosus
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