eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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SCImago Journal & Country Rank
2/2021
vol. 46
 
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abstract:
Review article

The role of vitamin A and vitamin D in the modulation of the immune response with focus on innate lymphoid cells

Tanja Džopalić
1
,
Biljana Božić-Nedeljković
2
,
Vladimir Jurišić
3

1.
Department of Immunology, University of Niš, Medical Faculty, Niš, Serbia
2.
Institute for Physiology and Biochemistry “Ivan Djaja” Belgrade, Faculty of Biology, University of Belgrade, Serbia
3.
Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Cent Eur J Immunol 2021; 46 (2): 264-269
Online publish date: 2021/08/07
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The immune system with its numerous and complex interactions helps to protect the host from pathogenic microorganisms, and enables cleaning of damaged tissues. It is also associated with constant “monitoring” of the appearance of malignant cells and their elimination that can occur in the human body. Such a role depends on many factors including adequate intake of nutrients, including vitamins. The effect of vitamin supplementation on the modulation of the immune response has always been the focus of numerous studies. Vitamins A and D have been shown to have the greatest immune-modulatory effect. In this review, we discuss and consider the possible roles of vitamins A and D on the immune response through innate and adaptive immune cells, with special focus on the cell population recently characterized as innate lymphoid cells. Recent literature data indicate that vitamin A and its metabolites modulate the balance between Th1 and Th2 immunity. In addition, vitamin D expresses protective effects on the innate immune system and inhibitory effects on adaptive immunity.
keywords:

vitamin A, vitamin D, immune response, innate lymphoid cells

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