eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
1/2020
vol. 37
 
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abstract:
Original paper

Thiol/disulphide balance in patients with psoriasis

Mustafa Aksoy
,
Adnan Kirmit

Adv Dermatol Allergol 2020; XXXVII (1): 52-55
Online publish date: 2018/08/27
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Introduction
Psoriasis is a common chronic inflammatory skin disease with unknown etiopathogenesis.

Aim
To examine the thiol/disulfide balance in psoriasis patients and to compare the results with a healthy control group.

Material and Methods
Eighty patients with psoriasis and 80 healthy individuals who were age- and gender-matched with these patients were included in this study. Serum native thiol, disulfide and total thiol levels were measured by a new automated method developed by Erel and Neselioglu. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol were calculated.

Results
While there was no statistically significant difference in terms of disulphide levels (SS) between the patient and control groups (p > 0.05), there were significant differences in terms of total thiol and native thiol (SH) levels, SS/SH, SS/total thiol and SH/total thiol ratios between the patient and control groups (p < 0.05). There was a statistically significant relationship between duration of the disease and the disulfide/native thiol ratio (p > 0.05).

Conclusions
In recent years, there have been few studies on the role of oxidative stress in the etiopathogenesis of psoriasis. In this study, we investigated in psoriasis patients, thiol/disulfide balance as a new oxidative stress marker. The results were compared with a healthy control group. Our results showed that thiol/disulphide balance shifted towards disulphide in psoriasis patients. This is important as a finding that supports the role of oxidative stress in the pathogenesis of psoriasis.

keywords:

disulphide, thiol, psoriasis

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