Thoracic SMARCA4-deficient undifferentiated tumour – a case of an aggressive neoplasm

Gizem Teoman

doi:10.5114/pjp.2025.149440

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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1/2025
vol. 76

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abstract:

Case report

Thoracic SMARCA4-deficient undifferentiated tumour – a case of an aggressive neoplasm

Gizem Teoman

¹

Karadeniz Technical University, Faculty of Medicine, Department of Pathology, Trabzon, Turkey

Pol J Pathol 2025; 76 (1): 70-74

DOI: https://doi.org/10.5114/pjp.2025.149440

Online publish date: 2025/04/11

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SMARCA4-deficient undifferentiated tumours exhibit undifferentiated and rhabdoid features. These highly aggressive neoplasms pose significant diagnostic challenges. They are characterised by an inactivating mutation of SMARCA4, leading to the loss of expression of Brahma-related gene 1 (BRG1). Despite their rareness and poor differentiation as thoracic tumours, it is important to recognise these tumours because, despite being highly aggressive, there are potential treatment options for the future, such as immunotherapy and SMARCA4-targeted therapies. This case presentation aims to raise awareness of this rare neoplasm when evaluating cases presenting undifferentiated morphology.

keywords:

Thoracic SMARCA4-deficient undifferentiated tumour – a case of an aggressive neoplasm

Gizem Teoman 1

SMARCA4, BRG1, lung, thorax

Gizem Teoman

¹