ISSN: 2451-0637
Archives of Medical Science - Civilization Diseases
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1/2021
vol. 6
 
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abstract:
Clinical research

Trabecular bone score and 3D-DXA in young, antiretroviral treatment-naïve patients in Madrid

Patricia Atencio
1
,
Rosa Arboiro-Pinel
2
,
Alfonso Cabello
1
,
Francisco M. Conesa-Buendía
3
,
Miguel Górgolas
1
,
Aránzazu Mediero
3
,
Manuel Díaz-Curiel
2

1.
Division of Infectious Diseases, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain
2.
Metabolic Bone Diseases Unit, Internal Medicine Department, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain
3.
Bone and Joint Research Unit, IIS-Fundación Jiménez Díaz. Universidad Autónoma de Madrid, Madrid, Spain
Arch Med Sci Civil Dis 2021; 6: e52–e60
Online publish date: 2021/05/05
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Introduction
Low bone mineral density (BMD) has been described as a non-AIDS-related event in human immunodeficiency virus (HIV)-patients, but it is poorly studied by dual-energy X-ray absorptiometry (DXA) and trabecular bone score (TBS) in young HIV-infected men who have received no previous antiretroviral treatment (ART).

Material and methods
A retrospective study of 56 naïve-HIV-infected men under 50 years old with recently diagnosed HIV infection, between May 2012 and July 2017.

Results
The mean age was 33.11 ±6.6 years, and they were 56.4% Caucasian and 43.6% Latin American. Regarding lifestyle and risk factors, 57% had previous exposure to tobacco and 31% reported drug use. Low BMD (Z-score < –2.0) was found in 21.4% of the patients, and partially degraded and degraded in 25% and 1.7%, respectively in TBS. We find significative prevalence of bone involvement among naïve HIV-infected men under 50 years old.

Conclusions
Further studies are necessary to evaluate if BMD assessment should be recommended in young HIV-infected patients.

keywords:

trabecular bone score, 3D-DXA, human immunodeficiency virus, naïve, bone mineral density

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