eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
4/2020
vol. 71
 
Share:
Share:
more
 
 
abstract:
Original paper

Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media

Dmitry Tretiakow
1
,
Jerzy Kuczkowski
1
,
Cecylia Tukaj
2

1.
Department of Otolaryngology, Medical University of Gdansk, Poland
2.
Department of Electron Microscopy, Medical University of Gdansk, Poland
Pol J Pathol 2020; 71 (4): 347-352
Online publish date: 2021/02/22
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Chronic otitis media with a retraction pocket is one of the forms of chronic otitis media that predisposes to cholesteatoma. The aim of our study was to determine the extent and type of changes in the tympanic membrane fragments which were surgically excised from the retraction pockets of 20 patients treated for cholesteatoma and/or hearing loss. Material evaluation and photographic documentation were performed using a transmission electron microscope (JEM 1200EX II, Jeol, Japan). We found that the morphological changes of the tympanic membrane are particularly related to the structure of the external epithelium, formation of epithelial invaginations, atrophy of the basement membrane of the eardrum and loss of circular and longitudinal collagen fibers. Ultrastructural changes in the tympanic membrane suggest inflammatory processes, epithelial migration, destruction of collagen fibers and autophagy, which indicates that the process of retraction pocket development is active. Tympanic membrane retraction pocket development is an active process, not the sequela of prior illness. The intensification of the keratinization and migration process of the epithelium layer confirms one of the theories of the creation of cholesteatoma and shows that the retention pocket is a pre-cholesteatoma condition.
keywords:

collagen fibers, transmission electron microscopy, retraction pocket, otitis, cholesteatoma

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe