eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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6/2020
vol. 16
 
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Pulmonology
abstract:
Clinical research

Usefulness of mean platelet volume to platelet count ratio for predicting the risk of mortality in community-acquired pneumonia

Jooyoung Cho
1
,
Saejin Lee
1
,
Young Uh
1
,
Jong-Han Lee
1

1.
Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea
Arch Med Sci 2020; 16 (6): 1327–1335
Online publish date: 2020/01/19
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Introduction
The association between mean platelet volume (MPV) to platelet count (PC) ratio and prognosis has been demonstrated in some diseases but not in community-acquired pneumonia (CAP). In this study, we evaluated the ability of MPV to PC ratio (MPR) to predict short-term mortality in CAP patients.

Material and methods
We retrospectively analysed data archived over 10 years and stratified MPR values into quartiles. Relations between MPR (femtoliters/number of thousand platelets per microlitre) quartiles and 60-day mortality were examined. Logistic regression was performed to adjust for confounders, and the Kaplan-Meier method was used for survival analysis.

Results
After adjusting for confounding factors, the odds ratios of 60-day mortality for CAP were 2.66 (95% CI: 2.04–3.46) for the fourth MPR quartile (range  5.19; p < 0.001) versus the first MPR quartile (range  2.45). Kaplan-Meier curves indicated that a higher MPR was associated with a higher risk of mortality among CAP patients, and this was confirmed by the log-rank test (p < 0.001).

Conclusions
Mean platelet volume to PC ratio was found to be positively correlated with short-term mortality. Our data indicate that MPR might be a significant predictive marker of the mortality in CAP. Further prospective studies are required to establish the exact role of MPR in CAP and other diseases.

keywords:

mean platelet volume to platelet ratio, mortality, community-acquired pneumonia

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