eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
5/2020
vol. 37
 
Share:
Share:
more
 
 
abstract:
Original paper

Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children

Monika Bobrowska-Korzeniowska
1
,
Agnieszka Brzozowska
1
,
Joanna Jerzyńska
1
,
Wlodzimierz Stelmach
2
,
Iwona Stelmach
1

1.
Department of Paediatrics and Allergy, N. Copernicus Memorial Hospital, Medical University of Lodz, Lodz, Poland
2.
Social Medicine Institute, Department of Social and Preventive Medicine, Medical University of Lodz, Lodz, Poland
Adv Dermatol Allergol 2020; XXXVII (5): 685-689
Online publish date: 2020/11/07
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
The usefulness of total specific resistance (sRtot) and interrupter resistance (Rint) as a bronchodilator reversibility test (BT) alternative to forced expiratory volume in 1 s (FEV1) in asthma diagnosis in children has not been established.

Aim
To compare different applied definitions of airflow obstruction in children measuring response to the bronchodilator by spirometry, plethysmography and the interrupter technique in asthmatic children.

Material and methods
Material and methods: It was a prospective, real-life, non-interventional study. Children, aged 6–18 with newly diagnosed asthma, able to perform lung function tests were included into the study. Subjects underwent a history taking, physical examination, reversibility test in spirometry, plethysmography, and the interrupter technique. A standard cut-off of 12% from the initial value for reversibility in FEV1 was employed. Improvement in the pre-bronchodilator sRtot and Rint ≥ 25% and ≥ 35% was assessed after administration of salbutamol (400 µg) as well as allergen sensitization were measured.

Results
We included 135 children diagnosed with asthma into the analysis. All investigated parameters changed statistically significantly due to the bronchodilator administration in the examined patients. The FEV1 was not as useful in diagnostics of asthma as the sRtot and Rint, taking into consideration the fait accompli that all the study participants had aptly been diagnosed as having asthma (p < 0.001). The differences between the sRtot and Rint were not statistically significant (p = 0.215).

Conclusions
Our results suggest that sRtot and Rint may be useful parameters in BT in clinical practice in the asthma diagnostic process in children.

keywords:

asthma, children, reversibility test, total specific resistance, interrupter resistance

Quick links
© 2020 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe