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ISSN: 1734-1922
Archives of Medical Science
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vol. 14
Clinical research

Variability of metabolic risk factors associated with prehypertension in males and females: a cross-sectional study in China

Bo Liu, Xiaoqi Dong, Yufei Xiao, Xianya Mao, Wensheng Pan, Das UN, Guangming Qin

Arch Med Sci 2018; 14, 4: 766–772
Online publish date: 2018/06/25
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Prehypertension is highly prevalent. However, very few studies have evaluated the association of various metabolic risk factors in those with prehypertension and, more importantly, possible differences based on gender.

Material and methods
Data of clinical characteristics were collected from 3891 subjects. Risk factors were analyzed by multiple logistic regression analysis. The areas under receiver operating characteristic curves were compared to assess the discriminatory value of metabolic parameters for predicting prehypertension.

The incidence of prehypertension was 55.9% (66.9% of men, 41.1% of women). Prehypertensives showed clusters of metabolic associations including changes in the levels of plasma high-density lipoprotein cholesterol (OR = 1.550), triglycerides (OR = 1.141) and fasting blood glucose (OR = 1.320) after adjusting for age, sex, body mass index and smoking. The metabolic associations also showed differences based on gender. For instance, higher total cholesterol (OR = 1.602) was the most evident risk factor in men with prehypertension, while higher triglycerides (OR = 1.314) and lower high-density lipoprotein cholesterol (OR = 1.729) were the main risk factors in women.

Our study suggests that risk associations of prehypertension show gender differences. These results emphasize the importance of health education, active management of blood pressure and timely and effective treatment of abnormal lipid profile in subjects with prehypertension.


prehypertension, gender, lipids, risk factor

Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289: 2560-72.
Wang Y, Wang QJ. The prevalence of prehypertension and hypertension among US adults according to the new joint national committee guidelines: new challenges of the old problem. Arch Intern Med 2004; 164: 2126-34.
Ishikawa Y, Ishikawa J, Ishikawa S, et al. Prevalence and determinants of prehypertension in a  Japanese general population: the Jichi Medical School Cohort Study. Hypertens Res 2008; 31: 1323-30.
Agyemang C, Owusu-Dabo E. Prehypertension in the Ashanti region of Ghana, West Africa: an opportunity for early prevention of clinical hypertension. Public Health 2008; 122: 19-24.
Egan BM, Stevens-Fabry S. Prehypertension: prevalence, health risks, and management strategies. Nat Rev Cardiol 2015; 12: 289-300.
Lüders S, Schrader J, Berger J, et al. The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril inpatients with high-normal blood pressure: a  prospective, randomized, controlled prevention trial of the German Hypertension League. J Hypertens 2008; 26: 1487-96.
Julius S, Nesbitt SD, Egan BM, et al. Feasibility of treating prehypertension with an angiotensin receptor blocker. N Engl J Med 2006; 354: 1685-97.
Vasan RS, Larson MG, Leip EP, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med 2001; 345: 1291-7.
Washio M, Tokunaga S, Yoshimasu K, et al. Role of prehypertension in the development of coronary atherosclerosis in Japan. J Epidemiol 2004; 14: 57-62.
Qureshi AI, Suri MF, Kirmani JF, Divani AA, Mohammad Y. Is prehypertension a  risk factor for cardiovascular diseases. Stroke 2005; 36: 1859-63.
Zhang Y, Lee ET, Devereux RB, et al. Prehypertension, diabetes, and cardiovascular disease risk in a  population-based sample: the Strong Heart Study. Hypertension 2006; 47: 410-4.
Grotto I, Grossman E, Huerta M, Sharabi Y. Prevalence of prehypertension and associated cardiovascular risk profiles among young Israeli adults. Hypertension 2006; 48: 254-9.
Huang Y, Cai X, Li Y, et al. Prehypertension and the risk of stroke: a  meta-analysis. Neurology 2014; 82: 1153-61.
Faselis C, Doumas M, Kokkinos JP, et al. Exercise capacity and progression from prehypertension to hypertension. Hypertension 2012; 60: 333-8.
Habib GB, Virani SS, Jneid H. Is 2015 the primetime year for prehypertension? Prehypertension: a  cardiovascular risk factor or simply a  risk marker? J Am Heart Assoc 2015; 4: pii: e001792.
Xu T, Liu J, Zhu G, Liu J, Han S. Prevalence of prehypertension and associated risk factors among Chinese adults from a  large-scale multi-ethnic population survey. BMC Public Health 2016; 16: 775.
Meng XJ, Dong GH, Wang D, et al. Epidemiology of prehypertension and associated risk factors in urban adults from 33 communities in China – the CHPSNE study. Circ J 2012; 76: 900-6.
Tabrizi JS, Sadeghi-Bazargani H, Farahbakhsh M, Nikniaz L, Nikniaz Z. Prevalence and associated factors of prehypertension and hypertension in Iranian population: the Lifestyle Promotion Project (LPP). PLoS One 2016; 11: e0165264.
Parthaje PM, Unnikrishnan B, Thankappan KR, Thapar R, Fatt QK, Oldenburg B. Prevalence and correlates of prehypertension among adults in urban South India. Asia Pac J Public Health 2016; 28: 93S-101S.
Alkerwi A, Baydarlioglu B, Sauvageot N, et al. Smoking status is inversely associated with overall diet quality: findings from the ORISCAV-LUX study. Clin Nutr 2016; 16: 30212-6.
Oda N, Kajikawa M, Maruhashi T, et al. Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men. Flow-mediated Dilation Japan (FMD-J) Study. Int J Cardiol 2017; 230: 523-8.
Liu LS, Writing Group of 2010 Chinese Guidelines for the Management of Hypertension. [2010 Chinese guidelines for the management of hypertension]. Zhonghua Xin Xue Guan Bing Za Zhi 2011; 39: 579-615.
Teramoto T, Sasaki J, Ueshima H, et al. Diagnostic criteria for dyslipidemia. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb 2007; 14: 155-8.
Isezuo SA, Sabir AA, Ohwovorilole AE, Fasanmade OA. Prevalence, associated factors and relationship between prehypertension and hypertension: a  study of two ethnic African populations in Northern Nigeria. J Hum Hypertens 2011; 25: 224-30.
Wang R, Lu X, Hu Y, You T. Prevalence of prehypertension and associated risk factors among health check-up population in Guangzhou, China. Int J Clin Exp Med 2015; 8: 16424-33.
Chockalingam A, Ganesan N, Venkatesan S, et al. Patterns and predictors of prehypertension among “healthy” urban adults in India. Angiology 2005; 56: 557-63.
Peng H, Ding J, Peng Y, et al. Hyperuricemia and microalbuminuria are separately and independently associated with prehypertension among Chinese Han women. Metab Syndr Relat Disord 2012; 10: 202-8.
Collier SR, Landram MJ. Treatment of prehypertension: lifestyle and/or medication. Vasc Health Risk Manag 2012; 8: 613-9.
Paoli A, Pacelli QF, Moro T, et al. Effects of high-intensity circuit training, low-intensity circuit training and endurance training on blood pressure and lipoproteins in middle-aged overweight men. Lipids Health Dis 2013; 12: 131.
Beck DT, Martin JS, Casey DP, Braith RW. Exercise training improves endothelial function in resistance arteries of young prehypertensives. J Hum Hypertens 2014; 28: 303-9.
Poorolajal J, Zamani R, Mir-Moeini R, et al. Five year evaluation of chronic diseases in Hanadan, Iran: 2005-2009. Iran J Public Health 2012; 41: 71-81.
Ghomari-Boukhatem H, Bouchouicha A, Mekki K, Chenni K, Belhadj M, Bouchenak M. Blood pressure, dyslipidemia and inflammatory factors are related to body mass index in scholar adolescents. Arch Med Sci 2017; 13: 46-52.
Kim Y, Lee S. Prevalence and risk factors associated with prehypertension by gender and age in a  Korean population in the KNHANES 2010-2012. Iran J Public Health 2015; 44: 1594-602.
Natali A, Muscelli E, Casolaro A, et al. Metabolic characteristics of prehypertension: role of classification criteria and gender. J Hypertens 2009; 27: 2394-402.
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