eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
4/2022
vol. 39
 
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abstract:
Original paper

Venous leg ulcers treated with fish collagen gel in a 12-week randomized single-centre study

Justyna Cwajda-Białasik
1, 2
,
Paulina Mościcka
1, 2
,
Maria T. Szewczyk
1, 2
,
Dorota Hojan-Jezierska
3
,
Weronika Kawałkiewicz
4
,
Anna Majewska
3
,
Marta Janus-Kubiak
4
,
Leszek Kubisz
4
,
Arkadiusz Jawień
5

1.
Department of Perioperative Nursing, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
2.
Outpatient Department for Chronic Wound Management, University Hospital No. 1, Bydgoszcz, Poland
3.
Department of Hearing Healthcare Profession, Chair of Biophysics, Poznan University of Medical Science, Poznan, Poland
4.
Department of Biophysics, Chair of Biophysics, Poznan University of Medical Science, Poznan, Poland
5.
Department of Vascular Surgery and Angiology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Adv Dermatol Allergol 2022; XXXIX (4): 714-722
Online publish date: 2021/08/16
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Introduction
Venous ulcers are difficult to heal chronic wounds. Most challenging are the non-healing and recurrent ulcers, because of which we are seeking for therapies that stimulate and support their healing. Aim: To assess the efficacy of fish collagen and its impact on the process of healing of venous leg ulcers.

Material and methods
This 12-week randomized single-centre study included a total of 97 adults with venous leg ulcer, randomized into two groups: the study group (n = 48) and the control group (n = 49). All patients received specialist medical care including skin and limb care, wound development according to the TIME scheme (tissue debridement, infection and inflammation control, moisture balance, edge) and short-stretch bandage compression (compression class II). In addition, the study group received tropocollagen gel applied to the skin around the wound. Every 2 weeks we evaluated the wound surface and temperature distribution on the shin (average temperature, median, minimum and maximum) – symmetrically on the sick and healthy limb.

Results
We observed a greater number of complete ulcer healing in the study group (week 12: 29.2% vs. 22.4%; week 24: 52.1% vs. 36.7%). Faster healing time in the study group was observed in both big and small ulcers. The thermographic analysis showed statistically significant reduction in periwound inflammation among patients from the study group (p < 0.05). Statistically significant reduction in mean as well as maximum values of limb temperature occurred only in the study group (Tx: R = 0.37, p < 0.001; Tmax: R = 0.40, p < 0.001).

Conclusions
Thermographic analysis showed better wound healing effects in the group using tropocollagen. Significant impact of collagen on the healing process was observed only after 8 weeks of application.

keywords:

venous leg ulcers, chronic wounds, fish collagen, planimetry, infrared thermography

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