eISSN: 1731-2531
ISSN: 1642-5758
Anaesthesiology Intensive Therapy
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
5/2021
vol. 53
 
Share:
Share:
abstract:
Review paper

Why is it worth remembering the lung microbiome in ICU patients?

Dorota Siwicka-Gieroba
1
,
Malgorzata Barud
1
,
Wojciech Dabrowski
1

1.
I Clinic of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Poland
Anaesthesiol Intensive Ther 2021; 53, 5: 466–474
Online publish date: 2021/11/07
View full text Get citation
 
PlumX metrics:
In recent years commensal microorganisms are not just “passive occupants”, but important element of homeostasis. There are numerous reports documenting the composition and role of the gut, skin or vagina microbiome but the role of commensal orga­nisms living in the lungs is relatively unknown. Pulmonary microbiome impact on the immune response of the host organism and may indicate new therapeutic directions. Lung microbiome, by modulating the expression of innate immunity genes, causes an increase in the concentration of interleukin (IL)-5, IL-10, interferon γ and C-C motif chemokine ligand 11, affects the toll-like receptor-4-dependent response of pulmonary macrophages and modulate the production of antibacterial peptides contained in the mucus. It is documented that disorders of the lung microbiome contribute to asthma or chronic obstructive pulmonary disease. However it is known that pulmonary dysbiosis also occurs in critically ill patients. It is possible, therefore, that microbiota-targeted therapy may constitute the future therapeutic direction in ICU.
keywords:

ICU, lung microbiome, lung-gut interaction

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.