eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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1/2018
vol. 14
 
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abstract:
Clinical research

Winter ambient training conditions are associated with increased bronchial hyperreactivity and with shifts in serum innate immunity proteins in young competitive speed skaters

Marcin Kurowski, Janusz Jurczyk, Sylwia Moskwa, Marzanna Jarzębska, Hubert Krysztofiak, Marek L. Kowalski

Arch Med Sci 2018; 14, 1: 60–68
Online publish date: 2017/12/19
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Introduction: Regular training modulates airway inflammation and modifies susceptibility to respiratory infections. The impact of exercise and ambient conditions on airway hyperreactivity and innate immunity has not been well studied. We aimed to assess exercise-related symptoms, lung function, airway hyperresponsiveness and innate immunity proteins in relation to meteorological conditions and exercise load in competitive athletes.

Material and methods: Thirty-six speed skaters were assessed during winter (WTP) and summer (STP) periods. The control group comprised 22 non-exercising subjects. An allergy questionnaire for athletes (AQUA) and IPAQ (International Physical Activity Questionnaire) were used to assess symptoms and exercise. Meteorological parameters were acquired from World Meteorological Organization resources. Serum innate immunity proteins were measured by ELISA.

Results: Exercise-associated respiratory symptoms were reported by 79.4% of skaters. Despite similar exercise load and lung parameters during both periods, positive methacholine challenge was more frequent during winter (p = 0.04). Heat shock protein HSPA1 and IL-1RA were significantly decreased during STP compared to WTP and controls. During WTP, IL-1RA was elevated in skaters reporting exercise-induced symptoms (p = 0.007). sCD14 was elevated in athletes versus controls in both periods (p < 0.05). HSPA1 was significantly higher in WTP compared to STP irrespective of presence of respiratory tract infections (RTIs). IL-1RA in WTP was elevated versus STP (p = 0.004) only in RTI-negative athletes. Serum IL-1RA negatively correlated with most meteorological parameters during WTP.

Conclusions: Ambient training conditions, but not training load, influence bronchial hyperreactivity and the innate immune response in competitive athletes assessed during winter. The protective effect of regular exercise against respiratory infections is associated with a shift in serum innate immunity proteins.
keywords:

interleukin-1 receptor antagonist protein, meteorological factors, exercise training, bronchial hyperreactivity, heat shock protein HSPA1, sCD14

references:
Gleeson M, Bishop N. URI in athletes: are mucosal immunity and cytokine responses key risk factors? Exerc Sport Sci Rev 2013; 41: 148-53.
Pokrywka A, Zembron-Lacny A, Baldy-Chudzik K, Orysiak J, Sitkowski D, Banach M. The influence of hypoxic physical activity on cfDNA as a new marker of vascular inflammation. Arch Med Sci 2015; 11: 1156-63.
Walsh N, Gleeson M, Shephard R, et al. Position statement. Part one: immune function and exercise. Exerc Immunol Rev 2011; 17: 6-63.
Gleeson M, Bishop N, Oliveira M, Tauler P. Influence of training load on upper respiratory tract infection incidence and antigen-stimulated cytokine production. Scand J Med Sci Sports 2013; 23: 451-7.
Nieman D. Immune response to heavy exertion. J Appl Physiol 1997; 82: 1385-94.
Kiwata J, Anouseyan R, Desharnais R, Cornwell A, Khodiguian N, Porter E. Effects of aerobic exercise on lipid-effector molecules of the innate immune response. Med Sci Sports Exerc 2014; 46: 506-12.
Cox A, Pyne D, Saunders P, Callister R, Gleeson M. Cytokine responses to treadmill running in healthy and illness-prone athletes. Med Sci Sports Exerc 2007; 39: 1918-26.
Nieman D, Henson D, Dumke C, Lind R, Shooter L, Gross S. Relationship between salivary IgA secretion and upper respiratory tract infection following a 160-km race. J Sports Med Phys Fitness 2006; 46: 158-62.
Robson-Ansley P, Howatson G, Tallent J, et al. Prevalence of allergy and upper respiratory tract symptoms in runners of London Marathon. Med Sci Sports Exerc 2012; 44: 999-1004.
Nieman D. Exercise, upper respiratory tract infection, and the immune system. Med Sci Sports Exerc 1994; 26: 128-39.
Spence L, Brown W, Pyne D, et al. Incidence, etiology, and symptomatology of upper respiratory illness in elite athletes. Med Sci Sports Exerc 2007; 39: 577-86.
Seys SF, Hox V, Van Gerven L, et al. Damage-associated molecular pattern and innate cytokine release in the airways of competitive swimmers. Allergy 2015; 70: 187-94.
Krzemiński K, Buraczewska M, Miśkiewicz Z, et al. Effect of ultra-endurance exercise on left ventricular performance and plasma cytokines in healthy trained men. Biol Sport 2016; 33: 63-9.
Kim K, Suzuki K, Peake J, et al. Physiological and leukocyte subset responses to exercise and cold exposure in cold-acclimatized skaters. Biol Sport 2014; 31: 39-48.
Niess A, Fehrenbach E, Lehmann R, et al. Impact of elevated ambient temperatures on the acute immune response to intensive endurance exercise. Eur J Appl Physiol 2003; 89: 344-51.
Bonini M, Gramiccioni C, Fioretti D, et al. Asthma, allergy and the Olympics: a 12-year survey in elite athletes. Curr Opin Allergy Clin Immunol 2015; 15: 184-92.
Bonini M, Braido F, Baiardini I, et al. AQUA: Allergy Questionnaire for Athletes. Development and validation. Med Sci Sports Exerc 2009; 41: 1034-41.
Craig C, Marshall A, Sjöström M, et al. International physical activity questionnaire: 12-country reliability and validity international physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 35: 1381-95.
American Thoracic Society. Guidelines for methacholine and exercise challenge testing – 1999. Am J Respir Crit Care Med 2000; 161: 309-29.
Anderson S, Kippelen P. Exercise-induced bronchoconstriction: pathogenesis. Curr Allergy Asthma Rep 2005; 5: 116-22.
Seys SF, Daenen M, Dilissen E, et al. Effects of high altitude and cold air exposure on airway inflammation in patients with asthma. Thorax 2013; 68: 906-13.
Rundell KW, Sue-Chu M. Air quality and exercise-induced bronchoconstriction in elite athletes. Immunol Allergy Clin North Am 2013; 33: 409-21.
Helenius I, Tikkanen H, Haahtela T. Occurrence of exercise induced bronchospasm in elite runners: dependence on atopy and exposure to cold air and pollen. Br J Sports Med 1998; 32: 125-9.
Hailes WS, Slivka D, Cuddy J, Ruby BC. Human plasma inflammatory response during 5 days of exercise training in the heat. J Therm Biol 2011; 36: 277-82.
Henson D, Nieman D, Kernodle M, Sonnenfeld G, Morton D, Thompson M. Immune function in adolescent tennis athletes and controls. Sports Med Training Rehab 2001; 10: 235-46.
Del Giacco SR, Scorcu M, Argiolas F, Firinu D, Del Giacco GS. Exercise training, lymphocyte subsets and their cytokines production: experience of an Italian professional football team and their impact on allergy. BioMed Res Int 2014; 2014: 429248.
Borges G, Rama L, Pedreiro S, et al. Differences in plasma cytokine levels between elite kayakers and nonathletes. Biomed Res Int 2013; 2013: 370354.
Ramos D, Olivo C, Quirino Santos Lopes F, et al. Low-intensity swimming training partially inhibits lipopolysaccharide-induced acute lung injury. Med Sci Sports Exerc 2010; 42: 113-9.
Vieira R, Toledo A, Silva L, et al. Anti-inflammatory effects of aerobic exercise in mice exposed to air pollution. Med Sci Sports Exerc 2012; 44: 1227-34.
Sugama K, Suzuki K, Yoshitani K, Shiraishi K, Kometani T. Urinary excretion of cytokines versus their plasma levels after endurance exercise. Exerc Immunol Rev 2013; 19: 29-48.
Gleeson M, Bishop N, Stensel D, Lindley M, Mastana S, Nimmo M. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 2011; 11: 607-15.
Bermon S. Airway inflammation and upper respiratory tract infection in athletes: is there a link? Exerc Immunol Rev 2007; 13: 6-14.
Fehrenbach E, Niess A, Voelker K, Northoff H, Mooren F. Exercise intensity and duration affect blood soluble HSP72. Int J Sports Med 2005; 26: 552-7.
Lødrup Carlsen K, Granum B. Soluble CD14: role in atopic disease and recurrent infections, including otitis media. Curr Allergy Asthma Rep 2007; 7: 436-43.
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