@Article{Świniarska2008,
journal="Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery",
issn="1731-5530",
volume="5",
number="1",
year="2008",
title="TorakochirurgiaNon-small cell lung cancer: patients after pneumonectomy require longer anticoagulant prophylaxis than after lobectomy",
abstract="  Background:    Surgical treatment of cancer is associated with the risk of thromboembolism. The question is: might the range of lung resection in patients operated on for non-small cell lung cancer (NSCLC) have an influence on the serum anticoagulant protein expression?    Aim:    To compare the blood coagulation activation in patients after pneumonectomy and lobectomy based on concentration of selected proteins in serum.   Material and methods:    A prospective study was carried out among a group of 40 patients: Thirty of them underwent lobectomy and ten pneumonectomy. In all cases the serum level of tissue factor (TF), tissue factor pathway inhibitor (TFPI), tissue factor pathway inhibitor/activated factor X complex (TFPI/Xa), thrombin-antithrombin complex (TAT), L-selectin, E-selectin,  P-selectin were measured on the 1st and 7th  postoperative day.    Results:    The results of selected protein levels obtained on the first day after surgery were similar in both groups. However, a significant increase of TF, TAT complex and E-selectin on the seventh postoperative day was detected in patients after pneumonectomy.   Conclusions:    Patients after pneumonectomy for NSCLC are at significantly higher risk of thromboembolism than patients after lobectomy. This suggests that antithrombotic prophylaxis should be prolonged in patients after pneumonectomy.",
author="Świniarska, Joanna
and Kowalewski, Janusz
and Żekanowska, Ewa
and Góralczyk, Krzysztof",
pages="31--37",
url="https://www.termedia.pl/-Torakochirurgia-Non-small-cell-lung-cancer-patients-after-pneumonectomy-require-longer-anticoagulant-prophylaxis-than-after-lobectomy,40,10017,1,1.html"
}