@Article{Sikorska2008,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="46",
number="1",
year="2008",
title="Subependymal plaques in scrapie-affected hamster brains \– why are they so different from compact kuru plaques?",
abstract="We report here routine thin-section and immunogold electron microscopic studies on diffuse plaques in scrapie-affected hamster brains. These plaques were not discernible by routine H\&E staining. Ultrastructurally, plaques were recognized as areas of low electron density containing haphazardly-oriented fibrils, but not as stellate compact structures typical of mouse scrapie models; hence we labelled them \“loose plaques\”. Following immunohistochemistry at the electron microscopy level, fibrils within plaques were heavily decorated with PrP-conjugated gold particles. Loose plaques were located beneath the basal border of the ependymal cells and around blood vessels in the adjacent subependymal neuropil. When dystrophic neurites containing electron-dense inclusion bodies, some of them autophagic vacuoles [59], were seen within the plaque perimeter, they always remained PrP-negative. Some microglial cells were observed in close contact with PrP-positive plaques, and secondary lysosomes within these cells were heavily decorated with gold particles.",
author="Sikorska, Beata
and Brown, Paul",
pages="32--42",
url="https://www.termedia.pl/Subependymal-plaques-in-scrapie-affected-hamster-brains-8211-why-are-they-so-different-from-compact-kuru-plaques-,20,10047,1,1.html"
}