@Article{Sobczuk2008,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="7",
number="2",
year="2008",
title="The ERCC4/XPF gene polymorphism in postmenopausal women with breast cancer",
abstract="  Background:  The ERCC4/XPF gene plays an important role in the DNA repair system.    Objective:  Arg415Gln polymorphism in the ERCC4/XPF gene in postmenopausal women with breast cancer was analysed. Material and methods. Blood samples were obtained from 100 women with breast cancer and controls (n=106). The polymorphisms were determined by PCR-RFLP.   Results:  The distribution of the genotypes of the Arg415Gln polymorphism of ERCC4/XPF in both controls and patients did not differ significantly (p>0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences (p>0.05) in genotype distributions or allele frequencies between subgroups assigned to histological stage.   Conclusion:  The results suggest that Arg415Gln polymorphism in ERCC4/XPF may not be linked with appearance and development of breast cancer.",
author="Sobczuk, Anna
and Smolarz, Beata
and Romanowicz-Makowska, Hanna
and Pertyński, Tomasz",
pages="81--84",
url="https://www.termedia.pl/The-ERCC4-XPF-gene-polymorphism-in-postmenopausal-women-with-breast-cancer,4,10322,1,1.html"
}