@Article{Joks2008,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="12",
number="4",
year="2008",
title="Prognostic significance of Bcl-2 gene protein family polymorphisms in patients with chronic lymphocytic leukaemia",
abstract="B-cell chronic lymphocytic leukaemia  (B-CLL) is the most frequent type of leukaemia in the western hemisphere. It is an incurable disease, and is characterized by expansion of monoclonal malignant lymphoid B cells expressing on the surface CD 19, CD22, CD79b, CD23, CD5, CD20 low, CD5 , k/l (+) low. Leukaemic cells are present in the peripheral blood, bone marrow, and lymphoid tissues. In patients with B-CLL survival and time to progression are highly variable. Failed apoptosis plays an important role in pathogenesis of B-CLL. We present recent data concerning the role of Bcl-2 family proteins in regulation of apoptosis in B-CLL. We focus special attention on the BCL-2, BAX, MCL-1 genes polymorfphisms as potential novel prognostic risk factors in B-CLL patients.",
author="Joks, Monika
and Lewandowski, Krzysztof",
pages="162--167",
url="https://www.termedia.pl/Prognostic-significance-of-Bcl-2-gene-protein-family-polymorphisms-in-patients-with-chronic-lymphocytic-leukaemia,3,10802,1,1.html"
}