@Article{Forma2008,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="7",
number="4",
year="2008",
title="The A/G (\–5) polymorphism in the promoter region of the metallothionein 2A gene and breast ductal carcinoma",
abstract="  Aim:  Polymorphisms in the promoter region of metallothionein genes resulting in variation of heavy metal detoxification may be associated with cancer risk. In the present work A/G (\–5) polymorphism in the promoter region of the metallothionein 2A gene (MT-2A) in ductal carcinoma of the breast was investigated.    Material and methods:  Genomic DNA isolated from 75 breast cancer patients and 100 volunteers was used to genotype MT-2A A/G (\–5). Polymorphism was determined by automated DNA sequencer ABI PRISM 377. GeneScan Analysis Software ver. 3.7 and DNA Sequencing Analysis Software ver. 3.4.1 was used for interpretation of results.    Results:  The distribution of the genotypes of the A/G (\–5) polymorphism in the promoter region of MT-2A in both controls and patients did not differ significantly (p>0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences (p>0.05) in genotype distributions or allele frequencies between subgroups assigned to different Bloom-Richardson grading.    Conclusions:  The results suggest that the A/G (\–5) polymorphism in the promoter region of the MT-2A gene may not be linked with neoplastic transformation of breast ductal carcinoma.",
author="Forma, Ewa
and Bryś, Magdalena
and Romanowicz-Makowska, Hanna
and Krajewska, Wanda Małgorzata",
pages="217--221",
url="https://www.termedia.pl/The-A-G-8211-5-polymorphism-in-the-promoter-region-of-the-metallothionein-2A-gene-and-breast-ductal-carcinoma,4,10974,1,1.html"
}