@Article{Filippatos2008,
journal="Archives of Medical Science",
issn="1734-1922",
volume="4",
number="3",
year="2008",
title="Clinical researchSmall dense LDL cholesterol and apolipoproteins C-II and C-III in non-diabetic obese subjects with metabolic syndrome",
abstract="  Introduction:  Apolipoprotein (apo) C-II is considered as an important activator of lipoprotein lipase (LPL) and is required for efficient lipolysis of triglyceride  (TG)-rich lipoproteins. In contrast, excess apo C-II inhibits LPL-mediated hydrolysis of TGs. Apo C-III is an inhibitor of LPL activity. These effects may influence the plasma levels of atherogenic small dense low-density lipoprotein cholesterol (sdLDL-C), since TG concentrations are markers of this subfraction.    Material and methods:  We examined the possible influence of apo C-II and C-III plasma levels on sdLDL-C concentration in obese patients with metabolic syndrome (MetS). Plasma apo C-II and C-III were determined by an immunoturbidimetric assay. Obese subjects (n=73) with MetS but without any clinically evident cardiovascular disease were enrolled.   Results:  TG, apo C-II and C-III plasma levels progressively increased when study participants were divided according to sdLDL-C tertiles (P<0.001 for all 3 trends). The apo C-III/C-II ratio was relatively constant (i.e. \&#187;2.5) for all tertiles of sdLDL-C. Stepwise multiple linear regression analyses showed that apo C-III levels independently correlated with TG levels, while TG and apo B levels were independently associated with sdLDL-C concentrations. Apo C-II and C-III significantly correlated with sdLDL-C in univariate analysis, but not in multivariate analysis.   Conclusions:  Apo C-II and C-III levels are not independent predictors of sdLDL-C levels in obese subjects with MetS.",
author="Filippatos, Theodosios D.
and Tsimihodimos, Vasilis
and Kostapanos, Michalis
and Kostara, Christina
and Bairaktari, Eleni T.
and Kiortsis, Dimitrios N.
and Tselepis, Alexandros D.
and Elisaf, Moses S.",
pages="263--269",
url="https://www.termedia.pl/Clinical-research-Small-dense-LDL-cholesterol-and-apolipoproteins-C-II-and-C-III-in-non-diabetic-obese-subjects-with-metabolic-syndrome,19,11197,1,1.html"
}