@Article{Kopczyńska2008,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="12",
number="6",
year="2008",
title="The influence of tumour progression on serum concentration  of HER2 receptor extracellular domain and metalloproteinase 9 in patients with uterine cervical cancer",
abstract="  Background:  HER2 receptor extracellular domain is proteolytically cleaved from the receptor by means of metalloproteinases. Increased serum concentrations of both HER2 ectodomain and metalloproteinase 9 are observed in various tumour types.   Aim of the study:  The aim of this study was to estimate serum HER2 ectodomain and MMP-9 concentration in relation to clinicopathological features (findings) in patients with uterine cervical cancer and to assess the correlation between concentrations of these proteins.   Material and methods:  The study group consisted of 40 patients with cervical cancer ranging in age from 30 to 79 years (mean age 52.4\±12.1). Serum ECDHER2  and MMP-9 concentrations were evaluated by ELISA.    Results:  Serum concentration of both ECDHER2 and MMP-9 was significantly higher in cervical cancer patients than in controls. The concentration of ECDHER2  was higher in patients with stage I than III (FIGO staging) and in the subgroup with stage I-II than with stage II-IV, and higher in patients with operable tumour than in inoperable. MMP-9 concentration increased together with tumour stage. It was significantly higher in patients with stage III than I and in the subgroup of patients with tumour advanced distantly (III-IV) than advanced locally (I-II), and it was higher in patients with tumour infiltrated sites behind the cervix uteri (II-IV) than in patients with tumour limited to the cervix uteri (I). ECDHER2  concentration was increased in 67.5% of patients, compared to MMP-9 concentration in 37.5%. Two markers, ECDHER2  and MMP-9, showed a weak negative correlation (r=\–0.19).   Conclusions:  In uterine cervical cancer patients the concentration of ECDHER2  decreases with tumour progression, while concentration of MMP-9 increases.",
author="Kopczyńska, Ewa
and Makarewicz, Roman
and Biedka, Marta
and Kardymowicz, Hanna
and Tyrakowski, Tomasz",
pages="261--266",
url="https://www.termedia.pl/The-influence-of-tumour-progression-on-serum-concentration-of-HER2-receptor-extracellular-domain-and-metalloproteinase-9-in-patients-with-uterine-cervical-cancer,3,11214,1,1.html"
}