@Article{Lipko-Godlewska2008,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="25",
number="5",
year="2008",
title="Original paperINF-\γ serum level in patients with morphoea and atrophoderma Pasini-Pierini considering clinical activity of disease",
abstract="  Introduction:  The fundamental component in the pathogenesis of systemic scleroderma, as well as localized scleroderma, is immunologically determined fibrosis. INF-\γ is considered to be a strong, natural fibrosis inhibitor. Low level of this cytokine was observed in other skin diseases with the course of fibrosis.    Aim:  The aim of the study was to measure INF-\γ level in serum collected from patients with localized scleroderma.   Material and methods:  The group of localized scleroderma patients comprised 18 patients with en plaque type of localized scleroderma (M), 18 patients with atrophoderma Pasini-Pierini (APP) and 5 patients with both types of skin lesions (M + APP). Control group serum was taken from 18 healthy volunteers. INF-\γ level was assessed with the ELISA method.   Results:  INF-\γ serum level was lower in all patients with localized scleroderma in comparison with the control group. INF-\γ serum level in patients with M + APP was also lower, whereas in patients with APP it was higher than in the control group. No statistical significance was observed. INF-\γ serum level was significantly (p=0.04) lower in patients with the active stage of M compared with patients with the inactive one. Moreover, it was lower \– but not significantly \– in the active stage of M + APP and the whole group of patients with localized scleroderma than in inactive ones. INF-\γ serum level was higher only in the active stage of APP. INF-\γ serum level correlated with the number and area of skin lesions in all LS patients. The higher the number of skin lesions present, the lower was the INF-\γ serum level observed. The lowest INF-\γ serum level was observed in patients with greater than 30 cm 2  area of skin affected by lesions (p=0.003).   Conclusions:  INF-\γ serum level was lower in all patients with localized scleroderma in comparison with the control group. Moreover, INF-\γ serum level was lower in the active stage of diseases in comparison with the inactive one. Serum level of INF-\γ might be a useful factor in predicting the intensity of skin fibrosis in localized scleroderma.",
author="Lipko-Godlewska, Sylwia
and Wojas-Pelc, Anna",
pages="214--219",
url="https://www.termedia.pl/Original-paper-INF-947-serum-level-in-patients-with-morphoea-and-atrophoderma-Pasini-Pierini-considering-clinical-activity-of-disease,7,11354,1,1.html"
}