@Article{Górska2008,
journal="Central European Journal of\ Immunology",
issn="1426-3912",
volume="33",
number="4",
year="2008",
title="Clinical immunologyInterleukin-6 and tumor necrosis factor alpha levels in the serum and synovial fluid in relation to bone mineral density and turnover in children with juvenile idiopathic arthritis",
abstract="  Aim of the study:    To evaluate the relationships between levels of proinflammatory cytokines (TNF-\&#945; and IL-6) and bone metabolism in juvenile idiopathic arthritis (JIA) children.    Methods:    Twenty children with active JIA were included, 12 with polyarticular type of JIA and 8 with oligoarticular onset. The control group consisted of 15 healthy children. TNF-\&#945; and IL-6 were measured in the serum and synovial fluid using ELISA Quantikine kits (R \& D Systems, USA). The levels of osteocalcin (N-MID Osteocalcin) and C-terminal type I alpha-collagen chain telopeptide (CTx) were determined in the Elecsys\&reg; 2010 system. Bone mineral density (BMD) was assessed by DXA method in the total bone (Total BMD, g/cm2) and in the L2-L4 vertebrae (SpineBMD, g/cm2) as Z-score.    Results:    In children with JIA, the mean serum IL-6 level was elevated as compared with the control group (34.5 pg/ml \&plusmn; 31.9 and 1.4 \&plusmn; 1.6 pg/ml, respectively, p<0.01). The level of TNF-\&#945; in JIA children was higher (9.3 pg/ml \&plusmn; 3.9) in comparison with the control group (4.7 pg/ml \&plusmn; 0.5), but the difference was not statistically significant. In both JIA forms, the level of IL-6 in synovial fluid was high (442.8 pg/ml \&plusmn; 162.2). The mean levels of N-MID Osteocalcin and CTx were increased as compared with the control group (96.3 ng/ml \&plusmn; 54.0 and 70.2 ng/ml \&plusmn; 48.3; 1.7 \&micro;g/dl \&plusmn; 0.5 and 1.2 \&micro;g/dl \&plusmn; 0.4, respectively). A significant positive correlation was observed between ESR and serum IL-6 level (p<0.04) and the degree of articular damage (p<0.001). There was a trend toward negative correlation between serum IL-6 and TNF-\&#945; levels and bone mineral density (p=0.05 for both).    Conclusions:    Elevated levels of IL-6, TNF-\&#945;, N-MID osteocalcin, CTx and significant correlations between inflammatory parametrs, articular destruction and bone mass loss were observed in patients with JIA.",
author="Górska, Anna
and Kowal-Bielecka, Otylia
and Urban, Mirosława
and Pietrewicz, Edyta",
url="https://www.termedia.pl/-Clinical-immunology-Interleukin-6-and-tumor-necrosis-factor-alpha-levels-in-the-serum-and-synovial-fluid-in-relation-to-bone-mineral-density-and-turnover-in-children-with-juvenile-idiopathic-arthriti,10,11566,1,1.html"
}