@Article{Gesing2008,
journal="Archives of Medical Science",
issn="1734-1922",
volume="4",
number="4",
year="2008",
title="Basic researchDoes L-thyroxine treatment downregulate EGF receptor expression in endemic non-toxic nodular goitre?",
abstract="  Introduction:  TSH receptor (TSH-R) is mainly expressed in thyroid follicular cells (TFC), regulating thyroid growth. Epidermal growth factor receptor (EGF-R) is often found upregulated in many human tumours. CD44 has been found to be implicated in thyroid tumour formation, carcinogenesis included, and has been selected in our study as a \“negative\” control for TSH-R and EGF-R, because no evidence exists for its regulatory effects on thyroid growth processes during L-thyroxine treatment.   Material and methods:  Fine-needle aspiration biopsies of the thyroid gland were performed in 18 adult patients with endemic non-toxic nodular goitre (NTNG) before and during L-thyroxine treatment (either 50 or 100 \µg/daily, depending on goitre volume and patient age) after 6 and/or 12 months, and TSH-R, EGF-R and CD44 expressions were assessed immunocytochemically in TFC.   Results:  Before L-thyroxine treatment \– positive immunoreactivity for EGF-R [EGF-R (+)], TSH-R [TSH-R (+)] and CD44 [CD44 (+)] was observed in 61, 72 and 82% of NTNG cases, respectively. During L-thyroxine therapy \– out of 5 original EGF-R (+) and out of 4 original immunonegative [EGF-R (\–)] cases, all were found EGF-R (\–); out of the original 7 TSH-R (+) cases, 86% became TSH-R (\–), but 2 TSH-R (\–) cases became TSH-R (+); out of 7 CD44 (+) cases, 71% remained CD44 (+).   Conclusions:  EGF-R expression is completely downregulated in the course of L-thyroxine treatment of endemic nodular goitre, the mechanism which could be considered as being involved in goitre involution.",
author="Gesing, Adam
and Lewiński, Andrzej
and Niewiadomska, Hanna
and Karbownik-Lewińska, Małgorzata",
pages="392--396",
url="https://www.termedia.pl/Basic-research-Does-L-thyroxine-treatment-downregulate-EGF-receptor-expression-in-endemic-non-toxic-nodular-goitre-,19,11751,1,1.html"
}