@Article{Wasiutyński2009,
journal="Central European Journal of\ Immunology",
issn="1426-3912",
volume="34",
number="1",
year="2009",
title="Experimental immunologyThe effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors",
abstract=" The aim  of the present study was to evaluate the effect of feeding mice Echinacea purpurea-containing drugs on 1) neovascular response induced in mice by L-1 sarcoma cells 3 days after intracutaneous grafting 2) morphology, angiogenic activity and VEGF concentration of murine sarcoma L-1 tumors 7 days after intracutaneous cells transplantation.   Material and Methods:   Echinacea purpurea-containing drugs: Immunal forte tablets (LEK, Slovenia) and Echinapur tablets (Herbapol Poznań), 0.6 mg per day. Animals: inbred Balb/c mice 8-10 weeks old. Tumor cells: murine L-1 sarcoma from Warsaw Cancer Center Collection. Methods: cutaneous angiogenesis assay according to Sidky and Auerbach, VEGF concentration measurement (ELISA) and histological evaluation of L-1 sarcoma tumors 7 days after transplantation of cells.   Results:   Echinapur diminished angiogenesis induced by murine L-1 sarcoma cells 3 days after intradermal cells injection. Both Echinapur and Immunal reduced VEGF concentration in L1 sarcoma tumor tissue, evaluated 7 days after intradermal cells grafting. There were no differences in mass and diameter of tumors between investigated and control groups. In Echinacea-fed groups, however, there were less small blood vessels at a margin of tumor.",
author="Wasiutyński, Aleksander
and Bałan, Barbara J.
and Skopińska-Różewska, Ewa
and Siwicki, Andrzej K.
and Skurzak, Henryk
and Chorostowska-Wynimko, Joanna
and Sommer, Ewa
and Mazurkiewicz, Michał",
pages="38--41",
url="https://www.termedia.pl/Experimental-immunology-The-effect-of-Echinacea-purpurea-on-the-morphology-angiogenic-activity-and-vascular-endothelial-growth-factor-VEGF-concentration-of-murine-L-1-sarcoma-tumors,10,12163,1,1.html"
}