@Article{Myśliwiec2009,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="4",
number="2",
year="2009",
title="Systemic Cu/Zn-SOD activation in patients with  pancreatic cancer",
abstract="  Introduction:    Reactive oxygen species (ROS) have been linked to pancreatic cancer for their potential to induce mitogenicity and to stimulate cell proliferation. Cu/Zn-SOD is emerging as an important element of the cellular antioxidant mechanisms.   Aim:    The aims of this study were to assess Cu/Zn-SOD levels in plasma of patients with pancreatic cancer treated surgically and to analyze the association of Cu/Zn-SOD with total peroxide levels, along with clinical and pathological data.   Material and methods:    We studied 31 patients with pancreatic cancer in comparison with 14 healthy subjects using ELISA techniques to determine Cu/Zn-SOD and total peroxides.    Results:    We demonstrated a 3-fold increase in plasma levels of Cu/Zn-SOD in patients with pancreatic cancer (p < 0.001) in comparison with the control group. Also, total plasma peroxide levels were higher in the pancreatic cancer group  (p < 0.001) than in the control group. As assessed at postoperative day 10, concentrations of Cu/Zn-SOD were enhanced in plasma of pancreatic cancer patients (p < 0.05) in contrast to total peroxides, which diminished postoperatively (p < 0.05). The levels of total peroxides were greater in patients with cancers of the pancreatic body when compared to those of the pancreatic head (p < 0.05).    Conclusions:  We have shown for the first time that systemic Cu/Zn-SOD and total peroxides are increased in patients with pancreatic cancer. Surgical treatment resulted in greater plasma Cu/Zn-SOD and lower peroxide levels.",
author="Myśliwiec, Piotr
and Kędra, Bogusław
and Kukliński, Adam
and Pawlak, Krystyna",
pages="74--78",
url="https://www.termedia.pl/Systemic-Cu-Zn-SOD-activation-in-patients-with-pancreatic-cancer,41,12240,1,1.html"
}