@Article{McGrowder2009,
journal="Archives of Medical Science",
issn="1734-1922",
volume="5",
number="1",
year="2009",
title="Hypocalciuria in pre-eclampsia and gestational hypertension due to decreased fractional excretion of calcium",
abstract="  Introduction:   This study investigated whether reduction in urinary calcium excretion is due to decreased fractional excretion of calcium, and evaluated the potential of urinary calcium to creatinine ratio as a screening test for pre-eclampsia.   Material and methods:   This prospective study involves 83 pregnant subjects: 29 with pre-eclampsia, 27 with chronic hypertension and 27 normotensive pregnant controls. Serial blood and urine specimens were obtained and analyzed in the third trimester (32 weeks to term).   Results:   The serum levels of calcium, phosphate, urea and uric acid were not different among the groups. In contrast, the serum albumin was significantly reduced in pre-eclamptic women and chronic hypertensive women, compared with normotensive pregnant controls. Pre-eclamptic women had the lowest urinary calcium excretion rate (1.70 \&#177;0.26 mmol/day) compared with chronic hypertensive women (4.23 \&#177;0.59 mmol/day, p < 0.05) and normotensive pregnant women  (4.43 \&#177;0.60 mmol/day, p < 0.05). Hypocalciuria in pre-eclamptic women was associated with decreased fractional excretion of calcium of 1.45 \&#177;0.05 mmol/day compared with 4.02 \&#177;0.09 mmol/day in normotensive women (p < 0.05). There was decreased urinary calcium to creatinine ratio (0.17 \&#177;0.03 mmol/mmol) in pre-eclamptic women compared with normotensive women (0.45 \&#177;0.08 mmol/mmol, p < 0.05).    Conclusions:   These findings suggest that hypocalciuria in pre-eclampsia is associated with decreased fractional excretion of calcium, suggesting a mechanism which may involve increased tubular reabsorption of calcium. Urinary calcium to creatinine ratio may be a useful potential screening test for pre-eclampsia.",
author="McGrowder, Donovan A.
and Williams, Algie
and Gordon, Lorenzo
and Crawford, Tazhmoye
and Alexander-Lindo, Ruby L.
and Irving, Rachael
and Hamilton, Michelle
and Fraser, Yeiny T.P.",
pages="80--85",
url="https://www.termedia.pl/Hypocalciuria-in-pre-eclampsia-and-gestational-hypertension-due-to-decreased-fractional-excretion-of-calcium,19,12290,1,1.html"
}