@Article{Catakoglu2009,
journal="Archives of Medical Science",
issn="1734-1922",
volume="5",
number="1",
year="2009",
title="The interaction between endothelin-1 and C-reactive protein and their impact on long-term prognosis after percutaneous coronary interventions",
abstract=" Introduction:  Previous studies have demonstrated unfavourable outcomes in coronary artery disease and percutaneous coronary intervention (PCI) patients with high endothelin-1 (ET-1) or high sensitivity C-reactive protein (hs-CRP) levels. The aim of our study was to investigate the impact of pre-procedural ET-1 and hs-CRP levels on major adverse coronary events (MACE) after PCI and to analyse a possible correlation between ET-1 and hs-CRP in this study population.   Material and methods:  Eighty consecutive PCI patients with a single de novo, non-occlusive coronary lesion were included. Blood samples were obtained immediately before the procedure. The study endpoint was the occurrence of MACE, which was defined as death (all causes), non-fatal myocardial infarction or repeat coronary revascularization (PCI or surgery).   Results:  At the end of the 24 months\’ follow-up, 28 patients (35%) reached an end-point. We could not observe any correlation between ET-1 and hs-CRP in the overall patient group (r = 0.141, p = 0.213). Neither ET-1 nor hs-CRP levels were found to be predictive for MACE after PCI in multivariate analyses (p = 0.605 and 0.757 respectively).   Conclusions:  We could not demonstrate a relationship between pre-procedural ET-1 or hs-CRP levels and MACE at 24 months after successful PCI with single stent implantation to single de novo lesions. This study also could not show any correlation between ET-1 and hs-CRP levels in PCI patients.",
author="Catakoglu, Alp Burak
and Aytekin, Vedat
and Demiroglu, Cemsid
and Aytekin, Saide",
pages="38--44",
url="https://www.termedia.pl/The-interaction-between-endothelin-1-and-C-reactive-protein-and-their-impact-on-long-term-prognosis-after-percutaneous-coronary-interventions,19,12294,1,1.html"
}