@Article{Hosseini2009,
journal="Archives of Medical Science",
issn="1734-1922",
volume="5",
number="1",
year="2009",
title="SHORT COMMUNICATIONBreast cancer risk not only was not associated  with CYP17/A2 allele but also was related to A1 allele",
abstract="  Introduction:   Breast cancer is the second most common cancer in the world and the most common cancer in Iranian women in terms of rate. The cytochrome P-450c17a (CYP17) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17a, which functions as a susceptibility factor in breast cancer.   Material and methods:   Three common polymorphisms have been described in the CYP17 gene. The variant creates a recognition site for the MspAI restriction enzyme, the common allele as A1 and the variant alleles A2 (\–34T \® C). In total 53 Iranian sporadic breast cancer affected women compared to the control group were studied by PCR-RFLP for CYP17 variant.    Results:   Even though the A2/A2 were reported as risk factors for breast cancer our results showed that the A1/A1 were a higher risk factor in our population. A2/A2 had an inhibitory effect in our patients [A1/A1 / A2/A2 odds ratio, 5.57 (95% confidence interval, 1.514-20.506) p = 0.008].   Conclusions:   We conclude that not only was A2/A2 in our patients not associated with breast cancer risk but also there is a reverse relation between presence of A1/A1 and increase of breast cancer risk.",
author="Hosseini, Mojgan
and Houshmand, Massoud
and Ebrahimi, Ahmad",
pages="103--106",
url="https://www.termedia.pl/SHORT-COMMUNICATION-Breast-cancer-risk-not-only-was-not-associated-with-CYP17-A2-allele-but-also-was-related-to-A1-allele,19,12301,1,1.html"
}