@Article{Skowronek2009,
journal="Journal of Contemporary Brachytherapy",
issn="1689-832X",
volume="1",
number="2",
year="2009",
title="Original articleTrans-hepatic technique and intraluminal Pulsed Dose Rate (PDR-BT) brachytherapy in treatment of locally advanced bile duct and pancreas cancer",
abstract=" Purpose:  To assess the feasibility of intraluminal palliative Pulsed Dose Rate (PDR-BT) brachytherapy in the treatment of locally advanced bile duct and pancreas cancer.   Material and methods:  Forty-eight patients with advanced bile duct or pancreas cancer, disqualified from surgery or radical external beam radiation therapy (EBRT), were treated with trans-hepatic technique and intraluminal PDR-BT: 29 patients with bile duct cancer and 19 \– pancreas cancer. Forty-four patients were treated exclusively with PDR-BT, 4 with PDR\–BT and concomitant chemotherapy or surgery. Percutaneous trans-hepatic technique was used to implant the catheter into bile ducts. Most of patients (38/48, 79%) received 25 pulses of 0.8 Gy hourly with the total dose of 20 Gy. In 8 cases PDR was repeated after one week. Target volume encompassed tumor visualized at cholangiography with one or two cm margin measured proximally and distally. Dose was prescribed at 10-15 mm from the source axis.    Results:  In all cases trans-hepatic technique allowed insertion of BT catheter into bile duct and safe application of PDR-BT. In 19 out of 29 (65.5%) of bile duct cancer cases and in 10 out of 19 (52.6%) of pancreas cancer patients clinical improvement (decrease of jaundice) was noted in first control after 4 weeks. Median overall survival time (OS) for bile ducts cancer patients was 11.2 months and for pancreas cancer patients \– 5.2 months.    Conclusions:  1. It has been established, that the use of PDR-BT was feasible and had a low early complication rate. A new percutaneous trans-hepatic technique allowed the treatment (insertion of catheter, PDR brachytherapy) to be performed in one day. 2. In most cases a satisfied palliative effect was achieved, however it was more apparent in bile duct cancer patients then in pancreas cancer patients.",
author="Skowronek, Janusz
and Sowier, Aleksander
and Skrzywanek, Paweł",
pages="97--104",
url="https://www.termedia.pl/Original-article-Trans-hepatic-technique-and-intraluminal-Pulsed-Dose-Rate-PDR-BT-brachytherapy-in-treatment-of-locally-advanced-bile-duct-and-pancreas-cancer,54,12805,1,1.html"
}