@Article{Franiak-Pietryga2009,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="8",
number="4",
year="2009",
title="The effect of atorvastatin on the erythrocyte plasma membrane and C-reactive protein in menopausal women with metabolic syndrome",
abstract="  The aim  of the study was to estimate the effect of atorvastatin (10 mg/d) on serum lipids, C-reactive protein and erythrocyte structure membrane (membrane cholesterol, the activity of Na+/K+-ATPase) in menopausal women with metabolic syndrome (MS).   Material and methods:  The study comprised 20 menopausal women (mean age 55 \&#177;3,69). Waist circumference ł 80 cm, triglycerides (TG) level >150 mg/dl (1,7 mmol/l), cholesterol HDL level < 50 mg/dl (1,3 mmol/l), systolic blood pressure (SBP) ł 130 mm Hg and/or diastolic blood pressure (DBP) ł 85 mm Hg were inclusion criteria for patients with MS. Control group consisted of 18 healthy women (mean age 55 \&#177;6,48). Before and after 4 and 12 weeks of treatment the following parameters were determined: serum lipids (total cholesterol \&#8211; TC, cholesterol LDL, cholesterol HDL, TG \&#8211; by means enzymatic method), hsCRP (immunoenzymatic method), membrane cholesterol in erythrocytes (method of Ilcy) and Na+/K+-ATPase activity (method of Bartosz et al.).   Results:  It was noticed significantly higher concentrations of hsCRP and membrane cholesterol in erythrocytes of menopausal women with MS. Atorvastatin caused a significant decrease, after 4 weeks therapy, in serum TC, cholesterol LDL, TG, hsCRP and membrane cholesterol (by 47%) in comparison with the initial values before active therapy. The activity of Na+/K+-ATPase has significantly changed after 12 weeks of therapy (increase by 29%). The mean values of TC, cholesterol LDL-C and membrane cholesterol after 12 weeks of therapy were similar to the control group.   Conclusions:  Three-months treatment of atorvastatin was enough efficient to compensate disorders in erythrocyte membrane structure of menopausal women with MS.",
author="Franiak-Pietryga, Ida
and Balcerak, Magdalena
and Sikora, Joanna
and Duchnowicz, Piotr
and Koter-Michalak, Maria
and Stetkiewicz, Tomasz
and Broncel, Marlena",
pages="233--238",
url="https://www.termedia.pl/The-effect-of-atorvastatin-on-the-erythrocyte-plasma-membrane-and-C-reactive-protein-in-menopausal-women-with-metabolic-syndrome,4,13108,1,1.html"
}