@Article{Wiśniewska-Jarosińska2009,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="8",
number="4",
year="2009",
title="Serotonin secretion and metabolism in postmenopausal women with gastrointestinal functional disorders",
abstract="In postmenopausal women ailments of the gastrointestinal tract often occur. Pathogenesis of these disorders is complex and remains to a large extent unknown. It has been suggested that one of the factors to be considered may be an impaired homeostasis of serotonin.   Aims:  The study aimed at evaluating serotonin secretion and urinary excretion of its major metabolite \&#8211;  5-hydroxyindole acetic acid in pre- and postmenopausal women.   Materials and methods:  The study comprised 50 women, aged 55\&#8211;63 years (mean age 57.3 \&#177;3.9), from two to twelve years after the last menstruation and 25 clinically healthy women \&#8211; the control group (K), aged 29\&#8211;36 years. In 25 of the studied patients functional dyspepsia (FD) was diagnosed, and in the other 25 functional constipation (FS). The diagnoses were based on the Rome III Criteria. Serotonin serum concentration and 5-hydroxyindole acetic acid in urine were measured by ELISA method applying IBL antibodies.   Results:  Serotonin serum concentration was as follows: in the controls (K) \&#8211; 163.52 \&#177;29.39 ng/ml, in women with FD \&#8211; 136.15 \&#177;27.58 ng/ml (p < 0.001) and in those with FC \&#8211; 139.67 \&#177;21.40 ng/ml (p < 0.01). The amount of 5-hydroxyindol acetic acid  in urine collection was respectively: K \&#8211; 5.77 \&#177;2.33 mg/24 h, FD \&#8211; 3.15 \&#177;2.52 mg/24 h (p < 0.01), FC \&#8211; 4.00 \&#177;2.13 mg/24 h (p < 0.05). The results obtained of both measured parameters negatively correlated with the symptoms severity.    Conclusions:    1. Serotonin secretion in women in the postmenopausal period is decreased.  2. Relative depletion of serotonin may be the cause of functional disorders of the gastrointestinal tract.",
author="Wiśniewska-Jarosińska, Maria
and Klupińska, Grażyna
and Kulig, Grażyna
and Walecka-Kapica, Ewa
and Chojnacki, Cezary",
pages="239--243",
url="https://www.termedia.pl/Serotonin-secretion-and-metabolism-in-postmenopausal-women-with-gastrointestinal-functional-disorders,4,13109,1,1.html"
}