@Article{Winiarska2009,
journal="Przegląd Kardiodiabetologiczny/Cardio-Diabetological Review",
issn="1896-9666",
year="2009",
title="Original paperPro-inflammatory activation of monocytes in patients with type 2 diabetes",
abstract=" Introduction:   Monocytes isolated from type 2 diabetic subjects exhibit increased pro-inflammatory and pro-atherogenic activity. Tumor necrosis factor-a (TNF-\α) secreted by monocytes seems to be a key cytokine inducing the progression of chronic inflammatory process and in consequence atherosclerosis.    Aim:   To evaluate whether TNF-\α mRNA expression in monocytes is related to metabolic and anthropometric parameters which express therapeutic effects.   Material and methods:   Monocytes from 22 with type 2 diabetes and from 15 healthy subjects were isolated in order to assess the expression of TNF-\α mRNA using real-time quantitative-PCR. All subjects were characterized with respect to metabolic (carbohydrate and lipid), anthropometric parameters (BMI, age) and TNF-\α serum levels.    Results:   The monocyte TNF-\α mRNA expression, as well as TNF-\α plasma concentrations, were significantly higher in patients with type 2 diabetes comparing to healthy controls. In type 2 diabetic group the monocyte TNF-\α mRNA expression was correlated with total cholesterol and LDL cholesterol serum levels. No correlation was found between other metabolic parameters, anthropometric markers, TNF-\α serum level and TNF-\α mRNA expression in monocytes.   Conclusions:   The results suggest that TNF-\α mRNA expression in monocyte from type 2 diabetic patients is closely related to lipid profile deteriorations. Therefore prevention of chronic inflammation leading to atherosclerosis development could be provided by the intensive therapy of hyperlipidaemia.",
author="Winiarska, Hanna
and Bobkiewicz-Kozłowska, Teresa
and Jagodziński, Paweł P.
and Kempisty, Bartosz
and Dworacka, Marzena",
pages="125--132",
url="https://www.termedia.pl/Original-paper-Pro-inflammatory-activation-of-monocytes-in-patients-with-type-2-diabetes,47,13447,1,1.html"
}