@Article{Najafi2009,
journal="Archives of Medical Science",
issn="1734-1922",
volume="5",
number="3",
year="2009",
title="Clinical researchEffect of N-acetylcysteine on microalbuminuria in patients with acute respiratory distress syndrome",
abstract=" Introduction:  Acute respiratory distress syndrome (ARDS) is associated with enlarged permeability of respiratory capillaries resulting in interstitial edema and microalbuminuria. This study investigated the effect of early treatment with N-acetylcysteine (NAC) on microalbuminuria/creatinine ratio and clinical improvement in ARDS.   Material and methods:  Twenty-three patients with ARDS were randomly entered into two groups of study including regular therapy and regular therapy plus NAC. NAC was started with 150 mg/kg on the first day followed by 50 mg/kg at the second day. Urine sample was tested for microalbuminuria on 4, 6, 12, 24, 36, and 48 h post baseline.   Results:  No significant correlation was found between microalbumin/creatinine ratio (MACR) and acute physiology and chronic health evaluation (APACHE II) or PaO2/FiO2 ratio and blood pressure in each group. Non-survivors showed higher urine albumin creatinine ratio (ACR) and physiologic scores than survivors. The patients outcome who treated with NAC showed significant improvement comparing with controls.   Conclusions:  NAC improves global hypoxemia in the patients with acute lung injury. Improvement of oxidant/antioxidant balance by NAC increases the survival of patients with ARDS who are under oxidative crisis. Although limitations of this study do not let us to reach a conclusive decision but the impact of microalbominuria as a predictive of survival in ARDS patients receiving NAC seems essential. Conducting larger clinical trials are recommended.",
author="Najafi, Atabak
and Mojtahedzadeh, Mojtaba
and Mahmoodpoor, Ata
and Aghamohammadi, Mostafa
and Ahmadi, Arezou
and Nahreini, Sheida
and Pazuki, Marzieh
and Reza Khajavi, Mohammad
and Abdollahi, Mohammad",
pages="408--414",
url="https://www.termedia.pl/Clinical-research-Effect-of-N-acetylcysteine-on-microalbuminuria-in-patients-with-acute-respiratory-distress-syndrome,19,13464,1,1.html"
}